2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 4

Topoisomerase I inhibitor 4 (compound 7a) 是 拓扑异构酶 I 的抑制剂。Topoisomerase I inhibitor 4 抑制 HepG2，A549，MCF-7 和 HeLa 细胞的增殖 IC50 值分别为 1.20，2.09，1.56 和 1.92 μM。Topoisomerase I inhibitor 4 可用于癌症的研究。

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Topoisomerase I inhibitor 4 Chemical Structure

Topoisomerase I inhibitor 4 Chemical Structure

CAS No. : 2485135-31-5

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Topoisomerase I inhibitor 4 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1].

IC50 & Target

IC50: 1.20 μM (HepG2), 2.09 μM (A549), 1.56 μM (MCF-7), 1.92 μM (HeLa)[1]
体外研究
(In Vitro)

Topoisomerase I inhibitor 4 (1-80 μM) shows Top1 inhibitory activity[1].
Topoisomerase I inhibitor 4 (0-40 μM; 48 h) inhibits proliferation of cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 4 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HepG2, A549, MCF-7 and HeLa cell lines
Concentration: 0-40 μM
Incubation Time: 48 hours
Result: Showed antiproliferative activities to HepG2, A549, MCF-7 and HeLa cells with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively.
分子量

386.42

Formula

C23H19FN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase I inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 42485135-31-5Topoisomerase I inhibitor4Topoisomerase I inhibitor-4TopoisomeraseHepG2A549MCF-7HeLaproliferationcancerLuotonin AanalogInhibitorinhibitorinhibit

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