2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 8

Topoisomerase I inhibitor 8 是一种强效 topoisomerase I 抑制剂。Topoisomerase I inhibitor 8 是一种喜树碱六环类似物，对肿瘤细胞有毒性。

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Topoisomerase I inhibitor 8 Chemical Structure

Topoisomerase I inhibitor 8 Chemical Structure

CAS No. : 210346-40-0

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规格 价格 是否有货
5 mg ￥580
询问价格 & 货期
10 mg ￥800
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Topoisomerase I inhibitor 8 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].

IC50 & Target

Topoisomerase I

 

体外研究
(In Vitro)

Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively[1].
Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 8 相关抗体:
分子量

420.43

Formula

C24H21FN2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase I inhibitor 8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 8210346-40-0Topoisomerase I inhibitor8Topoisomerase I inhibitor-8Topoisomerasecamptothecinhexacyclic analogueantitumor activity,Inhibitionketonespeptides and proteinstoxicityInhibitorinhibitorinhibit

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产品名称：
Topoisomerase I inhibitor 8
目录号：
HY-148058
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