1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. TPN171

TPN171 

目录号: HY-128593
产品使用指南

TPN171 是一种有效选择性的、有口服活性的五型磷酸二酯酶 (PDE5) 抑制剂,IC50 值为 0.62 nM,被开发用于肺动脉高压 (PAH) 的治疗。

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TPN171 Chemical Structure

TPN171 Chemical Structure

CAS No. : 1229018-87-4

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Description

TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1].

IC50 & Target[1]

PDE5

0.62 nM (IC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

441.57

Formula

C₂₄H₃₅N₅O₃

CAS No.

1229018-87-4

SMILES

CCCOC1=C(C2=NC(CC)=C(CC)C(N2)=O)C=C(NC(CN3CCN(C)CC3)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
TPN171
目录号:
HY-128593
需求量:

TPN171

Cat. No.: HY-128593