2. Apoptosis
  3. Apoptosis
  4. Tricin 7-O-β-D-glucopyranoside

Tricin 7-O-β-D-glucopyranoside 

目录号: HY-N9587
产品使用指南

摩尔计算器

Tricin 7-O-β-D-glucopyranoside 是一种有效的，具有口服活性神经保护剂。Tricin 7-O-β-D-glucopyranoside 诱导细胞凋亡 (Apoptosis)。Tricin 7-O-β-D-glucopyranoside 降低 TNF-α 诱导的磷-κB-α、磷-NF-κB、HMGB1 的表达。

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Tricin 7-O-β-D-glucopyranoside Chemical Structure

Tricin 7-O-β-D-glucopyranoside Chemical Structure

CAS No. : 32769-01-0

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Tricin 7-O-β-D-glucopyranoside 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1[1].

体外研究
(In Vitro)

Tricin 7-O-β-D-吡喃葡萄糖苷 (4-64 µM；12 小时) 在 SH-SY5Y 细胞中缺氧葡萄糖诱导 3 小时，然后孵育 12 小时后，以剂量依赖性方式诱导细胞凋亡[1] 。
Tricin 7-O-β-D-glucopyranoside (16, 32 µM; 12 h) 降低 SH-SY5Y 细胞 中 TNF-α (20 ng/ml，30 分钟) 诱导的磷酸化-κB-α、磷酸化-NF-κB、HMGB1 的表达 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tricin 7-O-β-D-glucopyranoside 相关抗体:

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 2, 4, 8, 16, 32, 64 µM
Incubation Time: 12 h
Result: Induced cell apoptosis after oxygen-glucose deprivation for 3 h followed by 12 h incubation with neurobasal medium with the apoptosis rate of 35.6%.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 16, 32 µM
Incubation Time: 12 h
Result: Blocked TNF-α (20 ng/ml for 30 min) induced IκB-α and NF-κB phosphorylation, and reduced HMGB1 expression.
体内研究
(In Vivo)

Tricin 7-O-β-D-glucopyranoside (50、100、200 和 400 mg/kg；口服) 对缺血和再灌注 (I/R) 大鼠具有神经保护潜力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats[1]
Dosage: 50, 100, 200 and 400 mg/kg
Administration: P.o.
Result: Decreased neurological deficit scores, reduced brain infarct volume and brain water content, inhibited NF-κB activation and reduced HMGB1 expression.
分子量

492.43

Formula

C23H24O12
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tricin 7-O-β-D-glucopyranoside 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tricin 7-O-β-D-glucopyranoside32769-01-0Apoptosisorally activeneuroprotectivep-NF-κBHMGB1p-κB-αSH-SY5Y cellsInhibitorinhibitorinhibit

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