Zuclopenthixol dihydrochloride  (Synonyms: (Z)-Clopenthixol dihydrochloride)

Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia^[1][2][3].

Zuclopenthixol（0.2 和 0.4 mg/kg）使动物表现出行为药理学特征，其特征是攻击性行为减少，但运动活动不受影响（0.2 mg/kg）。相比之下，最高剂量（0.4 mg/kg）产生的抗攻击作用伴随着不动性的显着增加。亚慢性处理后，未观察到 Zuclopenthixol 产生的抗攻击性或运动活性的耐受性^[1]。
Zuclopenthixol（0.7 和 1.4 mg/kg）显着升高 MDA 水平。然而，两种剂量水平对大鼠脑 MDA 水平的影响没有差异。给予 1.4 mg/kg Zuclopenthixol 显著降低动物的 GSH 水平。尽管如此，较低剂量的药物并不影响大鼠脑内 GSH 水平。接受 0.7 或 1.4 mg/kg Zuclopenthixol 的动物表现出比 SCO 处理的动物显著更高的 GSH 水平。与媒介物处理的动物相比，给予 0.7 mg/kg Zuclopenthixol 显著提高 GSHPx 活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

473.89

C₂₂H₂₇Cl₃N₂OS

58045-23-1

固体

Light yellow to yellow

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23(9):439-45.  [Content Brief]

  [2]. Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):11-5.  [Content Brief]

  [3]. Bryan EJ, et al. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev. 2017 Nov 16;11(11):CD005474.   [Content Brief]