1. Neuronal Signaling
  2. Serotonin Transporter

Cinchonidine (Synonyms: α-Quinidine)

目录号: HY-N0173 纯度: >98.0%
产品使用指南

Cinchonidine (α-Quinidine) 是在金鸡纳和角蒿中发现的金鸡纳生物碱。 Cinchonidine (α-Quinidine) 是用于有机化学中不对称合成的砌块。是血清素转运蛋白 (SERT)的弱抑制剂,对于dSERT,hSERT,hSERT I172M,hSERT S438T,hSERT Y95F的 Ki 分别为330,4.2,36,196,15 μM。有抗疟活性.。

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Cinchonidine Chemical Structure

Cinchonidine Chemical Structure

CAS No. : 485-71-2

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550 In-stock
100 mg ¥500 In-stock
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500 mg   Get quote  

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Description

Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities[1].

IC50 & Target

Ki: 330 μM (dSERT), 4.2 μM (hSERT), 36 μM (hSERT I172M), 196 μM (hSERT S438T), 15 μM (hSERT Y95F) [1]

In Vitro

Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3969 mL 16.9843 mL 33.9685 mL
5 mM 0.6794 mL 3.3969 mL 6.7937 mL
10 mM 0.3397 mL 1.6984 mL 3.3969 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

294.39

Formula

C₁₉H₂₂N₂O

CAS No.

485-71-2

SMILES

C=C[C@H]1C[N@](CC[C@H]1C2)[C@]2([H])[C@H](O)C3=CC=NC4=CC=CC=C34

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Cinchonidine
目录号:
HY-N0173
需求量:

Cinchonidine

Cat. No.: HY-N0173