1. Metabolic Enzyme/Protease
  2. CETP

CETP

Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that promotes reverse cholesterol transport via the exchange of cholesteryl ester (CE) and triglyceride (TG) among lipoproteins. Cholesteryl ester transfer protein (CETP) promotes reverse cholesterol transport via exchange of cholesteryl ester and triglyceride among lipoproteins. CETP has a central role in lipoprotein metabolism.

CETP, a hydrophobic plasma glycoprotein, is a promising target for raising circulating HDL cholesterol (HDL-C) concentrations in humans. CETP is secreted primarily from the liver and plays a critical role in HDL metabolism by facilitating the exchange of cholesteryl esters (CE) from HDL for triglycerides (TG) in apoB-containing lipoproteins, such as LDL and VLDL.

CETP catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in modulating plasma HDL cholesterol levels in humans is well established and there have been significant efforts to develop CETP inhibitors to increase HDL cholesterol for the treatment of coronary artery disease.

CETP 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-14950
    Dalcetrapib Inhibitor 99.75%
    Dalcetrapib (JTT-705; RO-4607381)是rhCETP抑制剂,IC50为0.2 μM,能增加血浆中HDL胆固醇。
  • HY-12090
    Anacetrapib Inhibitor 99.29%
    Anacetrapib 是一种有效的 CETP 抑制剂,作用于 rhCETP 和 C13S CETP 突变型,IC50 分别为 7.9±2.5 nM 和 11.8±1.9 nM。
  • HY-13327
    Evacetrapib Inhibitor
    Evacetrapib 是一种有效的选择性的 CETP 抑制剂,在人血浆中,抑制人重组 CETP 蛋白 (IC50 为 5.5 nM) 和 CETP 活性,IC50 为 36 nM。
  • HY-12089
    Torcetrapib Inhibitor 99.40%
    Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。