1. Metabolic Enzyme/Protease
  2. Factor Xa

Factor Xa

Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is an enzyme, a serine endopeptidase, which plays a key role at several stages of the coagulation system. Factor X is synthesized in the liver. Factor Xa has emerged as an attractive target for novel anticoagulants for its key position in the coagulation cascade and its limited roles outside of coagulation. The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. As a result, the past decade has witnessed an explosion of research into small-molecule, oral, direct Factor Xa inhibitors, and several are now in clinical development.

Factor Xa 相关产品 (14):

Cat. No. Product Name Effect Purity
  • HY-50903
    Rivaroxaban Inhibitor 99.96%
    Rivaroxaban 是一种高效的选择性Factor Xa (FXa) 抑制剂,具有强效抗FXa活性 (IC50 为 0.7 nM,Ki 为 0.4 nM)。
  • HY-50667
    Apixaban Inhibitor 99.97%
    Apixaban 是一种高度选择性的,可逆的 Factor Xa 抑制剂,抑制人和兔的 Factor Xa,Ki 值分别为 0.08 nM 和 0.17 nM。
  • HY-10264B
    Edoxaban tosylate monohydrate Inhibitor 99.85%
    Edoxaban(DU-176)是口服的FXa抑制剂。
  • HY-B0597
    Fondaparinux sodium Inhibitor >98.0%
    Fondaparinux sodium 是一种抗凝血酶依赖性的 factor Xa 抑制剂。
  • HY-10268
    Betrixaban Inhibitor 98.85%
    Betrixaban 是一种口服有效的选择性factor Xa (fXa)抑制剂,IC50 为 1.5 nM。
  • HY-76948
    5-R-Rivaroxaban Inhibitor 99.72%
    5-R-Rivaroxaban 是 Rivaroxaban 的 R 型对映体。Rivaroxaban (BAY 59-7939) 是一种有效的选择性 Factor Xa (FXa) 抑制剂。
  • HY-B0385
    Gabexate mesylate Inhibitor 98.51%
    Gabexate甲磺酸盐是非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
  • HY-B0428A
    Ozagrel sodium Inhibitor 99.91%
    Ozagrel sodium (OKY-046 sodium) 是一抗血小板化合物,血栓素A2合成酶抑制剂。
  • HY-70035
    Otamixaban Inhibitor
    Otamixaban(FXV673)是高效的fXa选择性可逆型抑制剂,Ki为0.5nM,能抑制游离型或凝血酶原酶结合型fXa。
  • HY-B0428
    Ozagrel Inhibitor 99.96%
    Ozagrel(OKY-046)是高选择性的血栓素a2(TXA2)合成酶抑制剂。
  • HY-19373
    RWJ-445167 Inhibitor
    RWJ-445167 是一种有效的 thrombinfactor Xa 双重抑制剂,Ki 值分别为 4.0 nM 和 230 nM,具有抗血栓形成的作用。
  • HY-10264A
    Edoxaban tosylate Inhibitor
    Edoxaban(DU-176)是口服的FXa抑制剂,临床开发用于中风预防。
  • HY-10264
    Edoxaban Inhibitor
    Edoxaban(DU-176)是口服的FXa抑制剂,临床开发用于中风预防。
  • HY-12631
    BMS-654457 Inhibitor
    BMS-654457是 (FXIa) 的小分子可逆抑制剂,与人和兔FXIa结合的Ki 值分别为 0.2 和 0.42 nM。
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