1. GPCR/G Protein
  2. GNRH Receptor

GNRH Receptor

GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

GNRH Receptor 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-16168A
    Degarelix Antagonist 99.92%
    Degarelix是一种竞争性促性腺激素释放激素受体(GnRHR)拮抗剂,用于治疗雄激素依赖性晚期前列腺癌。
  • HY-13665
    Leuprolide Acetate Agonist 99.88%
    Leuprolide(Leuprorelin)醋酸盐是GnRH类似物,是脑垂体GnRH受体激动剂。
  • HY-17405
    Alarelin Acetate Agonist 99.61%
    Alarelin acetate是合成的GnRH激动剂。
  • HY-12551
    Triptorelin Agonist 98.44%
    Triptorelin是一个GnRH兴奋剂,能够抑制雌二醇引起的细胞增殖。
  • HY-13673A
    Goserelin acetate Agonist 99.95%
    Goserelin (ICI 118630)乙酸盐是GnRH激动剂。
  • HY-14369
    Elagolix sodium Antagonist 99.20%
    Elagolix sodium 是一种人的 GnRH 受体 (GnRHR) 拮抗剂,其 IC50Ki 值分别为 0.25 和 3.7 nM。
  • HY-P0009A
    Cetrorelix Acetate Antagonist 98.88%
    Cetrorelix是一个强的GnRH受体拮抗剂,IC50是1.21 nM.
  • HY-12556
    Deslorelin Agonist 99.94%
    Deslorelin是GnRH的激动剂。
  • HY-P0057
    Nafarelin Agonist 98.99%
    Nafarelin是GnRH的激活剂,能够刺激LH和FSH的分泌。
  • HY-16474
    Relugolix Antagonist >98.0%
    Relugolix是一个新颖的,非肽的能够口服的GnRH拮抗剂,IC50值是0.33 nM.
  • HY-12555
    Gonadorelin acetate Agonist 98.74%
    Gonadorelin醋酸盐是一种类似于促性腺激素释放激素(GnRH)的人造蛋白。
  • HY-13534
    Abarelix Antagonist 98.11%
    Abarelix 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于治疗前列腺癌。
  • HY-14789
    Elagolix Antagonist 99.57%
    Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。
  • HY-13581A
    Buserelin Acetate Agonist 99.98%
    Buserelin (INN) Acetate是一个GnRH的激动剂。
  • HY-P0051
    Lecirelin Agonist
    Lecirelin是一个合成的GnRH类似物,在治疗牛卵巢滤泡囊肿中有很好的作用。
  • HY-13673
    Goserelin Agonist
    Goserelin(ICI 118630)是注射型促性腺激素释放激素(GnRH)超激动剂。
  • HY-12553
    Leuprorelin Agonist
    Leuprolide是一种垂体GnRH受体激动剂。