1. GPCR/G Protein
  2. Vasopressin Receptor

Vasopressin Receptor

Vasopressin receptors are a family of tissue-specific G protein-coupled receptors, which classified into V1, V2 and V3 subtypes. These three subtypes differ in localization, function and signal transduction mechanisms. Although all three of these proteins are G-protein coupled receptors (GPCRs), activation of AVPR1A and AVPR1B stimulate phospholipase C, while activation of AVPR2 stimulates adenylate cyclase. These three receptors for vasopressin have unique tissue distributions. AVPR1A are expressed in vascular smooth muscle cells, hepatocytes, platelets, brain cells, and uterus cells. AVPR1B are expressed in cells of the anterior pituitary and throughout the brain, especially in the pyramidal neurons of the hippocampal CA2 field. AVPR2 are expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed in the liver where stimulation releases a variety of clotting factors into the bloodstream.

Vasopressin Receptor 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-18347A
    Conivaptan hydrochloride Antagonist 99.92%
    Conivaptan hydrochloride 是一种非肽段类的 vasopressin receptor 拮抗剂,能够抑制大鼠肝脏的 V1A 受体 和 肾脏的 V2 受体,Ki 值分别为 0.48 和 3.04 nM。
  • HY-17000
    Tolvaptan Antagonist 99.92%
    Tolvaptan是精氨酸加压素受体2拮抗剂,能抑制AVP-诱导的血小板聚集,IC50为1.28μM。
  • HY-17370
    Desmopressin Acetate Inhibitor 99.76%
    Desmopressin(DDAVP)醋酸盐是抗利尿激素精氨酸加压素类似物。
  • HY-18346
    Mozavaptan Antagonist 98.94%
    Mozavaptan (OPC31260)是有口服活性的非肽阴道加压素(vasopressin)V2受体拮抗剂,其IC50值为14nM。
  • HY-14185
    Lixivaptan Antagonist 99.57%
    Lixivaptan (VPA-985, WAY-VPA 985) 是具有口服活性,选择性的 vasopressin receptor V2 拮抗剂,对人和大鼠的 IC50 值分别为1.2 和 2.3 nM。
  • HY-12554
    Terlipressin Agonist 99.07%
    Terlipressin是一个强的血管收缩剂,能通过小动脉的平滑肌细胞上受体V1,
  • HY-12981
    RG7713 Antagonist 99.49%
    RG7713 (RO5028442) 是一种高效且有选择性的脑-渗透加压素 1a (V1a) 受体拮抗剂,其 Ki 值为 1 nM (hV1a) 和 39 nM (mV1a)。
  • HY-15009
    Fuscoside Antagonist >98.0%
    Fuscoside (OPC-21268) 是一种口服有效的非多肽类加压素受体 (vasopressin V1) 拮抗剂, IC50 值为0.4 μM。
  • HY-17370A
    Desmopressin Inhibitor
    Desmopressin(DDAVP)是抗利尿激素精氨酸加压素的合成类似物。
  • HY-19381
    WAY-151932 Agonist
    WAY-151932 是抗利尿激素 V2 受体激动剂,在人 V2V1a 结合实验中,IC50 分别为 80.3 和778 nM。
  • HY-109024
    Balovaptan Antagonist
    Balovaptan 是一种高效的,选择性的,可透过血脑屏障的后叶加压素 1a 受体 (vasopressin 1a (hV1a) receptor) 拮抗剂,对人和小鼠 (hV1a, mV1a) 受体的 Ki 值分别为 1 和 39 nM,可用于自闭症的研究。
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