1. Epigenetics
  2. Histone Acetyltransferase
  3. YF-2

YF-2 

目录号: HY-16531 纯度: 99.36%
产品使用指南

YF-2 是一种高度选择性、可透过血脑屏障的组蛋白乙酰转移酶 (histone acetyltransferase) 激动剂,能够在海马区乙酰化 H3,对 CBP,PCAF 和 GCN5 的 EC50 值分别为 2.75 μM,29.04 μM 和 49.31 μM,对 HDAC 无作用。具有抗肿瘤和抗阿尔滋海默症的活性。

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YF-2 Chemical Structure

YF-2 Chemical Structure

CAS No. : 1311423-89-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3850 In-stock
5 mg ¥3500 In-stock
10 mg ¥5500 In-stock
50 mg ¥16500 In-stock
100 mg ¥26500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

IC50 & Target[1]

CBP

2.75 μM (EC50)

PCAF

29.04 μM (EC50)

GCN5

49.31 μM (EC50)

In Vitro

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

In Vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (290.12 mM)

H2O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3210 mL 11.6050 mL 23.2099 mL
5 mM 0.4642 mL 2.3210 mL 4.6420 mL
10 mM 0.2321 mL 1.1605 mL 2.3210 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.83 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

430.85

Formula

C₂₀H₂₂ClF₃N₂O₃

CAS No.

1311423-89-8

SMILES

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
YF-2
目录号:
HY-16531
需求量:

YF-2

Cat. No.: HY-16531