1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Apovincaminic acid hydrochloride salt

Apovincaminic acid hydrochloride salt 

目录号: HY-133813A 纯度: ≥95.0%
COA 产品使用指南

Apovincaminic acid hydrochloride salt 是 Vinpocetine (VP) 的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminic acid hydrochloride salt 具有神经保护作用。

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Apovincaminic acid hydrochloride salt Chemical Structure

Apovincaminic acid hydrochloride salt Chemical Structure

CAS No. : 72296-47-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1210
In-stock
1 mg ¥500
In-stock
5 mg ¥1100
In-stock
10 mg ¥1750
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].

体内研究
(In Vivo)

Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation[1].
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1]
Dosage: 10 mg/kg
Administration: I.p. twice daily for 4 days
Result: Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests.
significantly reduced lesion size microglia activation.
分子量

358.86

Formula

C20H23ClN2O2

CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 50 mg/mL (139.33 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7866 mL 13.9330 mL 27.8660 mL
5 mM 0.5573 mL 2.7866 mL 5.5732 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

参考文献

Apovincaminic acid hydrochloride salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7866 mL 13.9330 mL 27.8660 mL 69.6651 mL
5 mM 0.5573 mL 2.7866 mL 5.5732 mL 13.9330 mL
10 mM 0.2787 mL 1.3933 mL 2.7866 mL 6.9665 mL
15 mM 0.1858 mL 0.9289 mL 1.8577 mL 4.6443 mL
20 mM 0.1393 mL 0.6967 mL 1.3933 mL 3.4833 mL
25 mM 0.1115 mL 0.5573 mL 1.1146 mL 2.7866 mL
30 mM 0.0929 mL 0.4644 mL 0.9289 mL 2.3222 mL
40 mM 0.0697 mL 0.3483 mL 0.6967 mL 1.7416 mL
50 mM 0.0557 mL 0.2787 mL 0.5573 mL 1.3933 mL
60 mM 0.0464 mL 0.2322 mL 0.4644 mL 1.1611 mL
80 mM 0.0348 mL 0.1742 mL 0.3483 mL 0.8708 mL
100 mM 0.0279 mL 0.1393 mL 0.2787 mL 0.6967 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Apovincaminic acid hydrochloride salt
目录号:
HY-133813A
需求量: