2. 诱导疾病模型产品 GPCR/G Protein MAPK/ERK Pathway
  3. 免疫与炎症疾病模型 Ras
  4. 半抗原
  5. CFL-137

CFL-137  (Synonyms: 2-萘酚-1-醛)

目录号: HY-W016889 纯度: 99.84%
COA 产品使用指南

摩尔计算器

CFL-137 是一种有效的 KRasG12C 抑制剂。CFL-137 具有抗增殖作用。CFL-137 显示出抗癌活性。CFL-137 具有肺癌研究的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CFL-137 Chemical Structure

CFL-137 Chemical Structure

CAS No. : 708-06-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
25 g ￥200
In-stock
50 g ￥320
In-stock
> 100 g   询价  

* Please select Quantity before adding items.

Customer Review

CFL-137 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].

IC50 & Target[1]

KRAS(G12C)

 

体外研究
(In Vitro)

CFL-137 (72 h) 显示出抗增殖作用，对 H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 细胞的 IC50 值分别为 11.4, 24.2, 24.5, 12.3, 43.3, 44.5, 27.63, 32.4, 46.9, 26.2, 25.0, 10.8, 66.2 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CFL-137 相关抗体:
体内研究
(In Vivo)

CFL-137 (5 mg/kg，5 次治疗；15 mg/kg，5 次治疗；30 mg/kg，3 次治疗；i.p.) 减少皮下人肺癌 H1792 (KRasG12C 突变体) 和 LCLC-103H (KRasWT) 小鼠肿瘤模型的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1]
Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments
Administration: I.p.
Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 32.5%.
分子量

172.18

Formula

C11H8O2
CAS 号
Unlabeled CAS

性状

固体

颜色

Light yellow to brown

中文名称

2-萘酚-1-醛
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料

纯度: 99.84%

COA (196 KB) HNMR (124 KB) RP-HPLC (179 KB)

产品使用指南 (1538 KB)
参考文献

CFL-137 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFL-137708-06-52-萘酚-1-醛CFL137CFL 137RasH1792LCLC-103Hanticancerantiproliferativelung cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CFL-137
目录号：
HY-W016889
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z