1. Anti-infection PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  2. Antibiotic Bacterial Akt GSK-3 β-catenin c-Myc
  3. Chrysomycin A

Chrysomycin A  (Synonyms: Chr-A)

目录号: HY-126771
产品使用指南

Chrysomycin A (Chr-A) 是一种抗生素,能够来源于链霉菌。Chrysomycin A 表现出抗肿瘤和抗结核和 MRSA 活性。特别是在胶质母细胞瘤中,Chrysomycin A 通过 Akt/GSK-3β/β-catenin 信号通路抑制癌细胞的增殖、迁移和侵袭。

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Chrysomycin A Chemical Structure

Chrysomycin A Chemical Structure

CAS No. : 82196-88-1

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250 μg ¥2916
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1].

体外研究
(In Vitro)

Chrysomycin A (0.2-1.8 μM; 48 h) 具有抗胶质母细胞瘤作用,抑制 U251 和 U87-MG 人胶质母细胞瘤的细胞活力,以及迁移和侵袭[1]
Chrysomycin A (0.2-1.8 μM; 48 h) 抑制 U251 和 U87-MG 细胞中 Akt/GSK-3β/β-Catenin 信号通路[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U251 and U87-MG human glioblastoma
Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
Incubation Time: 48 hours
Result: Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively.

Western Blot Analysis[1]

Cell Line: U251 and U87-MG human glioblastoma
Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
Incubation Time: 48 hours
Result: Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1.
分子量

508.52

Formula

C28H28O9

CAS 号
性状

固体

颜色

Light yellow to yellow

初始来源

marine-derived strain Streptomyces sp. 891

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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