2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. DCG-IV

DCG-IV 是一种有效的 II 类 mGluRs 受体激动剂，对 mGlu2R 和 mGlu3R 的 EC50 值为 0.35 和 0.09 μM。DCG-IV 也是 I 组 (IC50: mGlu1R/5R=389/630 μM) 和 III 组受体 (IC50: mGlu4R/6R/7R/8R=22.5/39.6/40.1/32 μM) 的竞争性拮抗剂。DCG-IV 具有抗惊厥和神经保护作用。

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DCG-IV Chemical Structure

DCG-IV Chemical Structure

CAS No. : 147782-19-2

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1 mg ￥6437
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DCG-IV 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

IC50 & Target[1]

mGluR2R

0.35 μM (EC50)

mGluR3R

0.09 μM (EC50)

mGluR1R

389 μM (IC50)

mGluR5

630 μM (IC50)

mGluR4R

22.5 μM (IC50)

mGluR6

39.6 μM (IC50)

mGluR7

40.1 μM (IC50)

mGluR8

32 μM (IC50)

体外研究
(In Vitro)

DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DCG-IV 相关抗体:
体内研究
(In Vivo)

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
Dosage: 10, 5, or 1 mg/kg
Administration: I.p.
Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
分子量

203.15

Formula

C7H9NO6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

DCG-IV 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCG-IV147782-19-2mGluRMetabotropic glutamate receptorsanticonvulsiveneuroprotective neurotoxicity locomotion behavioralchangesInhibitorinhibitorinhibit

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产品名称：
DCG-IV
目录号：
HY-101335
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