2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor 5-HT Receptor
  4. Dothiepin

Dothiepin  (Synonyms: Dosulepin; Dothep)

目录号: HY-12394
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摩尔计算器

Dothiepin (Dosulepin; Dothep) 是一种具有镇静/抗焦虑活性的抗抑郁剂。Dothiepin 是一种更倾向于抑制去甲肾上腺素摄取而不是血清素摄取的抑制剂。Dothiepin 通过抑制神经元摄取促进去肾上腺素能神经传递。Dothiepin 也是组胺 H1 受体拮抗剂，无心脏毒性。Dothiepin 在心因性面部疼痛、特发性纤维肌痛综合征或类风湿关节炎中表现出显著的镇痛活性。

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Dothiepin Chemical Structure

Dothiepin Chemical Structure

CAS No. : 113-53-1

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规格 价格 是否有货 数量
1 mg ￥2000
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Other Forms of Dothiepin:

Dothiepin 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].

IC50 & Target

Histamine H1-receptor, Noradrenaline uptake (α1-and α2-adrenoceptors and serotonin 5HT1 and 5HT2-receptors)[1]
Clinical Trial
分子量

295.44

Formula

C19H21NS
CAS 号
中文名称

度硫平
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dothiepin 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dothiepin113-53-1Dosulepin Dothep度硫平Histamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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