2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Eletriptan

Eletriptan  (Synonyms: UK-116044)

目录号: HY-A0039
产品使用指南

摩尔计算器

Eletriptan (UK-116044) 是一种高选择性且具有口服活性的 5-HT1B 和 5-HT1D 受体激动剂，pKi 分别为 8.0 和 8.9。Eletriptan 对大鼠神经源性炎症标志物有抑制作用。Eletriptan 可用于偏头痛的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Eletriptan hydrobromide 通常具有更好的水溶性和稳定性。

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Eletriptan Chemical Structure

Eletriptan Chemical Structure

CAS No. : 143322-58-1

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规格 是否有货
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Eletriptan 的其他形式现货产品:

Customer Review

Other Forms of Eletriptan:

Eletriptan 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].

IC50 & Target[1]

5-HT1B Receptor

8.0 (pKi)

5-HT1D Receptor

8.9 (pKi)

体内研究
(In Vivo)

Eletriptan (10, 30, 100, 300 and 1000 µg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

382.52

Formula

C22H26N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eletriptan 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eletriptan143322-58-1UK-116044UK116044UK 1160445-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1Dmigraineneurogenic inflammationcarotid blood floworally activeInhibitorinhibitorinhibit

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