Csf1r - colony stimulating factor 1 receptor Gene

中文名称：集落刺激因子1 受体

种属: Mus musculus

同用名: Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R

关于 Csf1r

功能概要

该基因编码的蛋白可启动多种功能，包括巨噬细胞集落刺激因子受体活性；蛋白质同二聚化活性；和蛋白磷酸酶结合活性。参与多个过程，包括神经系统发育；蛋白质磷酸化的正调节；和蛋白质磷酸化。位于细胞表面和质膜。 CSF1-CSF1R 复合体的一部分。以多种结构表达，包括消化系统；中枢神经系统;胚外成分；泌尿生殖系统；和肢体。该基因的人类直系同源物与轴突球体和色素性胶质细胞和肾细胞癌的成人发病白质脑病有关。与人 CSF1R（集落刺激因子 1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]