Eif4e - eukaryotic translation initiation factor 4E Gene

种属: Mus musculus

同用名: If4e; eIF-4E; EG668879; Eif4e-ps

基因 ID: 13684 | 基因类型: protein coding

关于 Eif4e

功能概要

This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on Other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Eif4e 基因产物(2)

mRNA	Protein	Name
NM_001313980.1	NP_001300909.1	eukaryotic translation initiation factor 4E isoform 2
NM_007917.4	NP_031943.3	eukaryotic translation initiation factor 4E isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mRNA cap binding	IDA IDA: 通过直接分析推断	11500381	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11500381	MGI
enables translation initiation factor activity	IDA IDA: 通过直接分析推断	16289705	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within behavioral fear response	IGI IGI: 通过遗传相互作用推断	24990923	MGI
acts upstream of or within cellular response to dexamethasone stimulus	IDA IDA: 通过直接分析推断	17556672	MGI
involved in mRNA export from nucleus	IDA IDA: 通过直接分析推断	8577715	MGI
involved in mRNA export from nucleus	IMP IMP: 通过突变表型推断	11500381	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: 通过突变表型推断	25456498	MGI
acts upstream of or within negative regulation of translation	IMP IMP: 通过突变表型推断	25456498	MGI
acts upstream of neuron differentiation	IMP IMP: 通过突变表型推断	25456498	MGI
involved in nuclear export	IDA IDA: 通过直接分析推断	15574771	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	IDA IDA: 通过直接分析推断	23263185	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	IEP IEP: 通过表达模式推断	23263185	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	IMP IMP: 通过突变表型推断	23263185	MGI
acts upstream of or within stem cell population maintenance	IGI IGI: 通过遗传相互作用推断	25456498	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: 通过突变表型推断	25456498	MGI
acts upstream of translation	IMP IMP: 通过突变表型推断	25456498	MGI
involved in translational initiation	IMP IMP: 通过突变表型推断	8577715	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatoid body	IDA IDA: 通过直接分析推断	22792342	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	12388085	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	11980711	MGI
is active in glutamatergic synapse	IEP IEP: 通过表达模式推断	11980711	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	23263185	MGI
located in nuclear body	IDA IDA: 通过直接分析推断	11500381	MGI
is active in postsynapse	IDA IDA: 通过直接分析推断	11980711	MGI
is active in postsynapse	IEP IEP: 通过表达模式推断	11980711	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

eukaryotic translation initiation factor 4E

eIF-4F 25 kDa subunit

mRNA cap-binding protein

相关产品

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-100022	Tomivosertib	Inhibitor	99.92%	Phase 2
HY-16366	Briciclib	Inhibitor	99.45%	Phase 1

Pre-clinical Phase

生物活性分子 (28)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19831	4EGI-1		98.32%	否
HY-14427	4E1RCat	Inhibitor	98.89%	否
HY-145974A	m7GpppAmpG ammonium		99.50%	否
HY-145262	eIF4E-IN-2	Inhibitor	98.76%	否
HY-100733	4E2RCat	Inhibitor	≥98.0%	否
HY-119271	CMLD010509		99.11%	否
HY-146805	EB1		99.91%	否
HY-114267	Cbz-B3A	Inhibitor	98.63%	否
HY-19831A	(Z)-4EGI-1	Inhibitor	≥98.0%	否
HY-RS04274	EIF4E Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-145309	eIF4E-IN-3	Inhibitor	/	否
HY-100022A	Tomivosertib hydrochloride	Inhibitor	/	否
HY-145240	eIF4E-IN-1	Inhibitor	/	否
HY-148664	eIF4E-IN-4	Inhibitor	/	否
HY-155337	eIF4E-IN-6	Inhibitor	/	否
HY-155676	eIF4E-IN-5	Inhibitor	/	否
HY-163479	MNK1/2-IN-7	Inhibitor	/	否
HY-176288	eIF4E/eIF4G PPI-IN-1		/	否
HY-176428	PROTAC MNK1 degrader-1		/	否
HY-RS04275	EIF4E2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS04276	EIF4E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W846144	ETP-45835	Inhibitor	/	否
HY-119271A	(-)-CMLD010509		/	否
HY-145974	m7GpppAmpG		/	否
HY-168326	Antiproliferative agent-64	Inhibitor	/	否
HY-172457	NUCC-0200808	Inhibitor	/	否
HY-RS17829	Eif4e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24297	Eif4e Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Eif4e	NCBI	NCBI:1977

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