Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

中文名称：受体相互作用的丝氨酸-苏氨酸激酶 3

种属: Mus musculus

同用名: Rip3; 2610528K09Rik

关于 Ripk3

功能概要

该基因编码的蛋白可启动 NF-kappaB 诱导激酶活性和蛋白丝氨酸/苏氨酸激酶活性。涉及多个过程，包括坏死性凋亡的执行阶段；造血或淋巴器官发育；和程序性细胞死亡的调节。作用于多个过程的上游或内部，包括 I-kappaB 激酶/NF-kappaB 信号；内在凋亡信号通路的正向调控；和蛋白质脱乙酰化的正调节。位于细胞质和细胞核中。以多种结构表达，包括消化系统；淋巴系统腺体；雄性生殖腺或器官；原条;和鼻甲骨原基。与人 RIPK3（受体相互作用丝氨酸/苏氨酸激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NF-kappaB-inducing kinase activity and protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]