Heparin calcium (MW 3600-5000)  (Synonyms: Nadroparin calcium (MW 3600-5000))

Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin^[1][2].

Heparin 是一种有效的抗凝血药物，因为它能够加速抗凝血酶抑制凝血级联中丝氨酸蛋白酶的速率。Heparin 和结构相关的 Heparan Sulfate (HY-101916) 是复杂的线性聚合物，由具有可变序列的不同长度的链的混合物组成。Heparin 与含有高正电荷密度互补结合位点的肽相互作用最紧密。 Heparin 和 Heparan Sulfate 主要表现出线性螺旋二级结构，其中磺基和羧基沿着多糖主链以规定的间隔和规定的方向显示。Heparin 与 DNA 类似，因为两者都是高电荷线性聚合物，具有聚电解质的作用。据信，Heparin 主要通过与 AT III 相互作用，增强 AT-III 介导的凝血因子（包括凝血酶和因子 Xa）的抑制作用，发挥抗凝剂的作用。Heparin 与 AT III 和凝血酶结合形成三元复合物，使抑制凝血酶的双分子速率常数增加 2000 倍。Heparin 主要位于与免疫反应密切相关的组织肥大细胞颗粒中。Heparin 与 FGF-2 和 FGFR-1 进行大量接触，稳定 FGF-FGFR 结合。Heparin 还与相邻 FGF-FGFR 复合物的 FGFR-1 接触，因此似乎促进 FGFR 二聚化^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Low-molecular-weight Heparin calcium (4 mg/kg; s.c. twice a day for 2 days) 可减轻 IRI SD 大鼠的骨骼肌损伤和全身炎症反应^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

37270-89-6

肝素钙(MW 3600-5000)； 那屈肝素钙(MW 3600-5000)； 钙保明(MW 3600-5000)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Capila I, et, al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.  [Content Brief]

  [2]. He J, et, al. Low-molecular-weight heparin calcium attenuates the tourniquet-induced ischemia-reperfusion injury in rats. Injury. 2021 Aug;52(8):2068-2074.  [Content Brief]