1. Metabolic Enzyme/Protease
  2. Cathepsin MMP
  3. Hepcidin-1 (mouse) (TFA)

Hepcidin-1 (mouse) (TFA) 

目录号: HY-P4373A 纯度: 98.94%
COA 产品使用指南

Hepcidin-1 (mouse) TFA 是一种参与铁稳态调节的内源性肽激素。Hepcidin-1 (mouse) TFA 上调 TRAP组织蛋白酶 KMMP-9 的 mRNA 水平并增加 TRAP-5b 蛋白分泌。Hepcidin-1 (mouse) TFA 下调 FPN1 蛋白水平并增加细胞内的铁。Hepcidin-1 (mouse) TFA 促进破骨细胞分化。

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Custom Peptide Synthesis

Hepcidin-1 (mouse) (TFA) Chemical Structure

Hepcidin-1 (mouse) (TFA) Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥1850
In-stock
5 mg ¥5600
In-stock
10 mg ¥9000
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Hepcidin-1 (mouse) (TFA):

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation[1].

IC50 & Target[1]

MMP-9

 

cathepsin K

 

体外研究
(In Vitro)

Hepcidin-1 (mouse) TFA (200-800 nM,4 天) 促进 RANKL (50 ng/mL) 诱导的 raw264.7 细胞分化[1]
Hepcidin-1 (mouse) TFA (0-800 nM,4 天) 上调 TRAP、CTK 和 MMP-9 mRNA 的表达[1]
Hepcidin-1 (mouse) TFA (0-800 nM,20 小时) 会增加 RAW264.7 细胞中 Trap-5b 蛋白的水平并降低铁转运蛋白 1 (FPN1) 蛋白[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 0, 200, 400, or 800 nM
Incubation Time: 20 h
Result: Decreased Ferroportin 1 (FPN1) protein.

RT-PCR[1]

Cell Line: RAW264.7 cells
Concentration: 0, 200, 400, or 800 nM
Incubation Time: 4 days
Result: Increased the gene expression of TRAP, CTK, and MMP-9 in a dose-dependent manner.
分子量

2754.24 (free base)

Formula

C111H169N31O35S8.xC2HF3O2

性状

固体

颜色

White to off-white

Sequence

Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)

Sequence Shortening

DTNFPICIFCCKCCNNSQCGICCKT (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.94%

参考文献

Hepcidin-1 (mouse) (TFA) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Hepcidin-1 (mouse) (TFA)
目录号:
HY-P4373A
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