2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. HSP Apoptosis Topoisomerase EGFR VEGFR
  4. HSP90-IN-13

HSP90-IN-13 (compound 5k) 是一种高效的 HSP90 广谱性抑制剂，IC50 为 25.07 nM。HSP90-IN-13 对 EGFR、VEGFR-2 和 Topoisomerase-2 具有多靶点活性。HSP90-IN-13 将 MCF-7 细胞周期阻滞在 G2/M 期，并通过线粒体介导途径诱导细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HSP90-IN-13 Chemical Structure

HSP90-IN-13 Chemical Structure

CAS No. : 2446055-29-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HSP90-IN-13 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].

IC50 & Target[1]

HSP90

25.07 nM (IC50)

Topoisomerase-2

25.85 nM (IC50)

EGFR

38.5 nM (IC50)

VEGFR-2

126.95 nM (IC50)

体外研究
(In Vitro)

HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%[1].
HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC50s of 4.47 μM, 7.55 μM and 4.04 μM, respectively[1].
HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC50 values of 38.5 nM, 126.95 nM and 25.85 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HSP90-IN-13 相关抗体:
分子量

483.54

Formula

C26H21N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSP90-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-132446055-29-2HSPApoptosisTopoisomeraseEGFRVEGFRHeat shock proteinsEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorAnticancerAnti-proliferativeHCT-116HelaMCF-7Mitochondrial pathwayMulti-targetInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HSP90-IN-13
目录号：
HY-146228
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z