MAO A/HSP90-IN-1 

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC₅₀ value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research^[1].

MAO A/HSP90-IN-1 (4-b) (0.1 μM-3 μM, 24小时) 通过抑制 MAO A 和 HSP90，从而减少 GBM 细胞的增殖^[1]。
MAO A/HSP90-IN-1 (0.1 μM-3 μM, 24小时) 在 GL26 中的 IC₅₀ 为0.73 μM，在GL26中的 IC₅₀ 为1.68 μM，在 U251R 中的 IC₅₀ 为0.84 μM^[1]。
MAO A/HSP90-IN-1 (0μM, 0.35μM, 0.7μM, 1.4μM, 24小时) 在小鼠胶质瘤 GL26 细胞中抑制IFN-_γ 诱导的PD-L1表达^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO A/HSP90-IN-1 (4-b) (25 mg/kg，腹腔注射，每天) 抑制 GBM 小鼠模型肿瘤生长^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

444.95

C₂₄H₂₉ClN₂O₄

2927489-95-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tseng HJ, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. Eur J Med Chem. 2023 Aug 5;256:115459.  [Content Brief]