2. Academic Validation
  3. Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals

Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals

  • Methods Find Exp Clin Pharmacol. 1980 Apr;2(2):65-9.
R A Ferrari,  K Chakrabarty,  J E Creange,  A L Beyler,  O G Potts,  H P Schane
PMID: 7339330
Abstract

Topterone, 17 alpha-propyltestosterone, was administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrated that topterone was both antiandrogenic and progestational. Topical application failed to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response was seen at 32 mg/kg/day. No other endocrine activities were detected.

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