2. Neuronal Signaling GPCR/G Protein Protein Tyrosine Kinase/RTK
  3. mGluR Src
  4. mG2N001

mG2N001 是代谢型谷氨酸受体 mGluR2 的负变构调节剂 (NAM) (IC50: 93 nM)，并作为拮抗剂与 mGluR2 结合 (Ki: 63 nM)。mG2N001 具有微粒稳定性和血浆稳定性，其放射性同位素 [11C]mG2N001 可用于 PET 成像。[11C]mG2N001 的脑异质性和脑渗透性好，能够选择性地积累在富含 mGluR2 的区域，产生高对比度的大脑图像。

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mG2N001 Chemical Structure

mG2N001 Chemical Structure

CAS No. : 2760515-88-4

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mG2N001 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Lck

  • 生物活性

  • 纯度 & 产品资料

生物活性

mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images[1].

体内研究
(In Vivo)

mG2N001 (63.0-87.3 MBq [11C]mG2N001, iv.) 可在大鼠和食蟹猴体内实行 PET 成像实验，表现出 mGluR2 的特异性结合活性，清楚显示动物脑中 mGluR2 的生物分布图[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

330.35

Formula

C18H19FN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

mG2N001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mG2N0012760515-88-4mGluRSrcMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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