2. NF-κB Immunology/Inflammation Apoptosis Stem Cell/Wnt MAPK/ERK Pathway Membrane Transporter/Ion Channel Neuronal Signaling
  3. NF-κB COX Apoptosis ERK Calcium Channel
  4. Recoflavone

Recoflavone  (Synonyms: DA-6034 free acid)

目录号: HY-106449 纯度: ≥98.0%
COA 产品使用指南 技术支持

Recoflavone (DA-6034 (free acid)) 是一种黄酮类化合物 Eupatilin (HY-N0783) 的合成衍生物，具有口服活性。Recoflavone 可抑制 NF-κB 通路。Recoflavone 也可诱导上皮细胞内钙离子浓度升高。Recoflavone 具有抗炎、抗肿瘤、胃黏膜、肠粘膜保护和促进眼表、唾液腺分泌等活性。Recoflavone 可用于干眼症、胃损伤和肠损伤等疾病的研究。

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Recoflavone Chemical Structure

Recoflavone Chemical Structure

CAS No. : 203191-10-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1837
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5 mg ￥1670
In-stock
10 mg ￥2680
In-stock
25 mg ￥5370
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50 mg 现货 询价
100 mg 现货 询价
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Customer Review

Recoflavone 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury[1][2][3][4].

体外研究
(In Vitro)

Recoflavone (100-250 µM; 24-48 h) 在人角膜上皮细胞中增加了黏蛋白样糖蛋白分泌[1]。
Recoflavone (200 µM; 24 h) 在人结膜上皮细胞中可显著增加一些粘蛋白的产生，包括 MUC1、MUC2、MUC4、MUC5AC、MUC5B 和 MUC16[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Recoflavone 相关抗体:
体内研究
(In Vivo)

Recoflavone (3%; 滴眼液; 单剂量) 在兔干眼病模型中显著减少了角膜损伤[1]。
Recoflavone (30 mg/kg; 口服; 每 12 小时 1 次; 3 天) 在大鼠小肠损伤模型中具有保护作用[2]。
Recoflavone (30 mg/kg; 灌胃; 每日 2 次; 第 7 到第 63 天) 在小鼠结肠炎相关癌症模型中具有改善作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male New Zealand White rabbits (2.5 kg) with desiccation-induced dry eye by keeping eyes open with a specula for 2 h[1]
Dosage: 3 %
Administration: Eye drops; single dose
Result: Significantly decreased methylene blue permeability in the cornea compared to the vehicle-treated group, indicating prevention of desiccation-induced corneal damage.
Animal Model: Sprague-Dawley rats aged 6 weeks old (250 g) treated Indomethacin (HY-14397) to induce small intestinal injury[2]
Dosage: 30 mg/kg
Administration: Oral administration; once every 12 hours; 3 days
Result: Increased the ERK expression.
Had significantly lower intestinal permeability compared with the control group, while the inflammation scores and the extent of hemorrhagic lesions showed no statistically significant differences.
Animal Model: C57BL/6 mice aged 10 weeks old (18-21 g) treated AOM (HY-111375) and DSS (HY-116282C) to induce colitis-associated cancer[3]
Dosage: 30 mg/kg
Administration: Oral gavage; twice daily; from day 7 to day 63
Result: Reduced the number of colon tumors.
Ameliorated weight loss and colon shortening.
Enhanced apoptosis , and inhibited the expression of proliferation marker Ki-67, COX-2, and phospho-IKKα in colon tissue.
Clinical Trial
分子量

386.35

Formula

C20H18O8
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 40 mg/mL (103.53 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5883 mL 12.9416 mL 25.8833 mL
5 mM 0.5177 mL 2.5883 mL 5.1767 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Recoflavone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5883 mL 12.9416 mL 25.8833 mL 64.7082 mL
5 mM 0.5177 mL 2.5883 mL 5.1767 mL 12.9416 mL
10 mM 0.2588 mL 1.2942 mL 2.5883 mL 6.4708 mL
15 mM 0.1726 mL 0.8628 mL 1.7256 mL 4.3139 mL
20 mM 0.1294 mL 0.6471 mL 1.2942 mL 3.2354 mL
25 mM 0.1035 mL 0.5177 mL 1.0353 mL 2.5883 mL
30 mM 0.0863 mL 0.4314 mL 0.8628 mL 2.1569 mL
40 mM 0.0647 mL 0.3235 mL 0.6471 mL 1.6177 mL
50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.2942 mL
60 mM 0.0431 mL 0.2157 mL 0.4314 mL 1.0785 mL
80 mM 0.0324 mL 0.1618 mL 0.3235 mL 0.8089 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6471 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Recoflavone203191-10-0DA-6034DA6034DA 6034NF-κBCOXApoptosisERKCalcium ChannelNuclear factor-κBNuclear factor-kappaBCyclooxygenaseExtracellular signal regulated kinasesCa2+ channelsCa channelsdry eye disease modelsmall intestinal injury modecolitis-associated cancer modelhuman corneal epithelial cellshuman conjunctival epithelial cellsInhibitorinhibitorinhibit

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