2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Ro 04-6790

Ro 04-6790 是一种有效的，竞争性和选择性的 5-HT6 受体拮抗剂，对大鼠和人的 5-HT6 受体的 pKi 值分别为 7.26、7.35。Ro 04-6790 对其他受体没有亲和力。

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Ro 04-6790 Chemical Structure

Ro 04-6790 Chemical Structure

CAS No. : 202466-68-0

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Ro 04-6790 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].

IC50 & Target[1]

Rat 5-HT6 Receptor

7.26 (pKi)

Human 5-HT6 Receptor

7.35 (pKi)

体外研究
(In Vitro)

Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 04-6790 相关抗体:
体内研究
(In Vivo)

Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

308.36

Formula

C12H16N6O2S
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ro 04-6790 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 04-6790202466-68-05-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-14335
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