2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. Ro 64-5229

Ro 64-5229 是一种选择性和非竞争性的 mGlu2 拮抗剂。RO 64-5229 能降低神经连接蛋白 1 的突触前抑制作用。

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Ro 64-5229 Chemical Structure

Ro 64-5229 Chemical Structure

CAS No. : 246852-46-0

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规格 价格 是否有货 数量
5 mg ￥3754
3 - 4 周
10 mg ￥6005
3 - 4 周
50 mg   询价  
100 mg   询价  

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Ro 64-5229 相关抗体

Top Publications Citing Use of Products

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1[1].

IC50 & Target

mGlu2[1].
体外研究
(In Vitro)

RO 64-5229 (50 µM) 降低神经连接蛋白 1 的突触前抑制作用[1]。
RO 64-5229 (0.1, 0.3, 1 µM; 20 min) 在 HEK-mGluR2 细胞中抑制 neuroligin 1 ectodomain (Ecto-NL1; mGluR2 激活剂) 对 Forskolin 的抑制活性 (Ecto-NL1 降低了 Forskolin 诱导的 cAMP 形成)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 64-5229 相关抗体:

Immunofluorescence[1]

Cell Line: HEK-mGluR2 cells
Concentration: 0.1, 0.3, 1 µM
Incubation Time: 20 min
Result: Inhibited activity of Ecto-NL1( mGluR2 activator).
分子量

352.26

Formula

C17H19Cl2N3O
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ro 64-5229 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 64-5229246852-46-0mGluRMetabotropic glutamate receptorsneuroligin 1NL1presynaptic inhibitoryInhibitorinhibitorinhibit

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产品名称：
Ro 64-5229
目录号：
HY-103557
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