2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. SR-1277

SR-1277 是一种有效、选择性和 ATP 竞争性的 CK1δ/ε 抑制剂，IC50 值分别为 49 nM 和 260 nM。SR-1277 还抑制 FLT3，CDK4/cyclin D1，CDK6/cyclin D3 和 CDK9/cyclin K，IC50 值分别为 305 nM，1340 nM，311 nM 和 109 nM。SR-1277 可用于癌症研究。

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SR-1277 Chemical Structure

SR-1277 Chemical Structure

CAS No. : 1446715-47-4

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SR-1277 相关抗体

Top Publications Citing Use of Products

查看 Casein Kinase 亚型特异性产品:

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CK1 CK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].

IC50 & Target[1]

CKIδ

49 nM (IC50)

体外研究
(In Vitro)

SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SR-1277 相关抗体:
体内研究
(In Vivo)

SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM•h), T1/2 (1.42 h) and brain penetration (24%) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

477.50

Formula

C21H19N9O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR-1277 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-12771446715-47-4SR1277SR 1277Casein KinaseCK1δCK1εFLT3CDK4cyclinD1CDK6D3CDK9KcancerInhibitorinhibitorinhibit

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