2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. WAY-181187 hydrochloride

WAY-181187 hydrochloride  (Synonyms: SAX-187 hydrochloride)

目录号: HY-W746031
产品使用指南

摩尔计算器

WAY-181187 (SAX-187) hydrochloride 是一种有效的选择性 5-HT6 受体激动剂，Ki 为 2.2 nM，EC50 为 6.6 nM。WAY-181187 hydrochloride 介导 5-HT6 受体依赖性信号通路，如 cAMP，Fyn 和 ERK1/2 激酶，作为特异性激动剂。

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WAY-181187 hydrochloride Chemical Structure

WAY-181187 hydrochloride Chemical Structure

CAS No. : 554403-08-6

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WAY-181187 hydrochloride 的其他形式现货产品:

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Other Forms of WAY-181187 hydrochloride:

WAY-181187 hydrochloride 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].

IC50 & Targetsup>[1]

5-HT6 Receptor

2.2 nM (Ki)

5-HT6 Receptor

6.6 nM (EC50)

体外研究
(In Vitro)

WAY-181187 (1 and 10 μM) hydrochloride 可增强 ERK1/2 的激活。WAY-181187 hydrochloride 还可提高 Fyn 激酶活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WAY-181187 hydrochloride 相关抗体:
体内研究
(In Vivo)

WAY-181187 (3-30 mg/kg, s.c.) hydrochloride 的急性给药显着增加细胞外 GABA 浓度，而不改变大鼠额叶皮质中谷氨酸或去甲肾上腺素的水平。 此外，WAY-181187 (30 mg/kg, s.c.) hydrochloride 可适度但显着降低皮质多巴胺和 5-HT 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats weighing 280-350 g[1]
Dosage: 3, 10, or 30 mg/kg
Administration: Acute dministered by s.c.
Result: Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.
分子量

417.33

Formula

C15H14Cl2N4O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WAY-181187 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-181187554403-08-6SAX-187WAY181187WAY 181187SAX187SAX 1875-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptoranxietyrelateddisordersOCD5-HT6cAMPFynERK1/2Inhibitorinhibitorinhibit

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目录号：
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