2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. WAY-181187 oxalate

WAY-181187 oxalate  (Synonyms: SAX-187 oxalate)

目录号: HY-110366
产品使用指南

摩尔计算器

WAY-181187 (SAX-187) oxalate 是一种有效的选择性 5-HT6 受体激动剂，Ki 为 2.2 nM，EC50 为 6.6 nM。WAY-181187 oxalate 介导 5-HT6 受体依赖性信号通路，如 cAMP，Fyn 和 ERK1/2 激酶，作为特异性激动剂。

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Custom Peptide Synthesis

WAY-181187 oxalate Chemical Structure

WAY-181187 oxalate Chemical Structure

CAS No. : 1883548-85-3

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WAY-181187 oxalate 的其他形式现货产品:

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Other Forms of WAY-181187 oxalate:

WAY-181187 oxalate 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2].

IC50 & Target

5-HT6 Receptor

2.2 nM (Ki)

5-HT6 Receptor

6.6 nM (EC50)

体外研究
(In Vitro)

WAY-181187 (1 and 10 μM) oxalate 可增强 ERK1/2 的激活。WAY-181187 oxalate 还可提高 Fyn 激酶活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WAY-181187 oxalate 相关抗体:
体内研究
(In Vivo)

WAY-181187 (3-30 mg/kg, s.c.) oxalate 的急性给药显着增加细胞外 GABA 浓度，而不改变大鼠额叶皮质中谷氨酸或去甲肾上腺素的水平。 此外，WAY-181187 (30 mg/kg, s.c.) oxalate 可适度但显着降低皮质多巴胺和 5-HT 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

470.91

Formula

C17H15ClN4O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WAY-181187 oxalate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-1811871883548-85-3SAX-187WAY181187WAY 181187SAX187SAX 1875-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptoranxietyrelateddisordersOCD5-HT6cAMPFynERK1/2Inhibitorinhibitorinhibit

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