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  2. HMG-CoA Reductase (HMGCR) Fungal
  3. β-Amyrin acetate

β-Amyrin acetate 

目录号: HY-N2923 纯度: 99.47%
COA 产品使用指南

β-Amyrin acetate 是一种三萜类化合物 (triterpenoid),具有有效的抗炎、抗真菌、抗糖尿病、抗高血脂活性。β-Amyrin acetate 可定位在 HMG CoA 还原酶 (HMG CoA reductase) 的 hydrophobic binding cleft,并抑制其活性。

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β-Amyrin acetate Chemical Structure

β-Amyrin acetate Chemical Structure

CAS No. : 1616-93-9

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase[1][2][3][4].

体外研究
(In Vitro)

β-Amyrin acetate (50 μg/mL) inhibits heat-induced hemolysis and hypotonicity-induced hemolysis of human erythrocytes[1].
β-Amyrin acetate (5-100 μM) has HMG-CoA reductase inhibitory activity by locating in the hydrophobic binding cleft lined with residues Leu562, Gly560, Ala564, Gly569, Ser852, Leu853, Leu857, Met854, Ala856, Ser852 and Ala855 of human HMG CoA reductase[2].
β-Amyrin acetate (7.8-1000 μg/mL, 48 h) inhibits all of the Candida fungal species tested with MIC values ranging from 30 to 250 μg/mL)[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

β-Amyrin acetate (applied on the anterior surface of the right ear, 100 μg/ear, a single dose) significantly inhibits xylene-induced ear edema in mice[1].
β-Amyrin acetate (intraperitoneal injection, 4 mg/100 g, daily for 6 consecutive days) shows significant anti-inflammatory activities (43.6%) in adult albino rats[3].
β-Amyrin acetate (subcutaneous injection, 4 mg/100 g, daily for 10 days ) increases the ATP-phosphohydrolase activity in liver homogenates both in normal and arthritic rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xylene-induced mouse ear topical edema model[1]
Dosage: 50 and 100 μg/ear (5 μL)
Administration: Applied on the anterior surface of the right ear
Result: Inhibited Xylene-induced ear edema in mice
Animal Model: Adult albino rats[3]
Dosage: 4 mg/100g, daily for 6 consecutive days
Administration: Intraperitoneal injection
Result: Showed significant anti-inflammatory activities with mean average weight of granulation tissue of 9.2 mg after 6 days.
分子量

468.75

Formula

C32H52O2

CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献
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  • 稀释计算器

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
β-Amyrin acetate
目录号:
HY-N2923
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