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  3. LY-2940094

LY-2940094 

目录号: HY-114452 纯度: 99.56%
产品使用指南

LY-2940094 是一种口服有效的选择性 nociceptin 受体 (NOP 受体) 拮抗剂,对 NOP 受体具有高亲和力(Ki 为 0.105 nM) 和拮抗活力 (Kb=0.166 nM)。LY-2940094 可降低动物模型的自身给药酒精依赖。

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LY-2940094 Chemical Structure

LY-2940094 Chemical Structure

CAS No. : 1307245-86-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥4950 In-stock
5 mg ¥4500 In-stock
10 mg ¥7500 In-stock
25 mg ¥15000 In-stock
50 mg ¥21000 In-stock
100 mg ¥33000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

LY-2940094 is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY-2940094 reduces ethanol self-administration in animal models[1].

IC50 & Target

Ki: 0.105 nM (NOP receptor)[1]
Kb: 0.166 nM (NOP receptor)[1]

In Vivo

LY-2940094 (LY2940094; 3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1].

Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1]
Dosage: 3, 10, or 30 mg/kg; 2-3 mL/kg
Administration: Administered orally; daily; 4 days
Result: Reduced homecage ethanol self-administration.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (86.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0792 mL 10.3959 mL 20.7917 mL
5 mM 0.4158 mL 2.0792 mL 4.1583 mL
10 mM 0.2079 mL 1.0396 mL 2.0792 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Suspended solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

480.96

Formula

C₂₂H₂₃ClF₂N₄O₂S

CAS No.

1307245-86-8

SMILES

OCC1=CC=CN=C1N2N=C(C)C(CN3CCC4(C5=C(C=C(Cl)S5)C(F)(F)CO4)CC3)=C2

Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
C1   V1   C2   V2

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产品名称:
LY-2940094
目录号:
HY-114452
需求量:

LY-2940094

Cat. No.: HY-114452