1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP). It is well known that p38 is involved in inflammation, apoptosis, cardiomyocyte hypertrophy and cell differentiation.

The p38 MAPK family is composed of four proteins: p38α (encoded by the gene Mapk14), p38β (Mapk11), p38γ (Mapk12), and p38δ (Mapk13). Their coding genes have a distinct tissue distribution and they appear differentially expressed, being Mapk14 the most highly expressed. p38 MAPKs are substrates for three MAP2K (MKK6, MKK3, and MKK4). The contribution of each of these MAP2K to p38 MAPKs activation depends on the stimulus and the cell type. The MAP3Ks that lead to p38 MAPKs activation are ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1.

p38 MAPK 相关产品 (32):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580 是一种 p38 MAPK 抑制剂,IC50 为 0.3-0.5 μM,也抑制 PKB 磷酸化,IC50 为 3-5 μM。
  • HY-10295
    SB 202190 Inhibitor 99.88%
    SB 202190 抑制 p38p38β2IC50 分别为 50 nM 和 100 nM。
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB 203580 hydrochloride 是一种 p38 MAPK 抑制剂,IC50 为 0.3-0.5 μM,也抑制 PKB 磷酸化,IC50 为 3-5 μM。
  • HY-10320
    Doramapimod Inhibitor 99.72%
    Doramapimod 是一种高效的 p38α 抑制剂,IC50 为 4 nM,也抑制 B-Raf 和 Abl,IC50 分别为 83 nM 和 14.6 μM。
  • HY-13241
    LY2228820 Inhibitor 99.94%
    LY2228820 是一种新颖的,有效的 p38 MAPK 抑制剂,IC50 值为 7 nM,但是不会改变 p38 MAPK 的活化。
  • HY-18874
    p38-α MAPK-IN-1 Inhibitor 99.92%
    p38-α MAPK-IN-1 是 MAPK14 (p38-α) 抑制剂,在 EFC 和 HTRF 实验中,IC50 值分别为 2300 nM 和 5500 nM。
  • HY-10402
    Losmapimod Inhibitor
    Losmapimod 是一种有效的,选择性的,可口服的 p38 MAPK 抑制剂,对 38α 和 p38β 的 pKi 值分别为 8.1 和 7.6。
  • HY-12048
    Chelerythrine Chloride Inhibitor >98.0%
    Chelerythrine Chloride 是一种有效的,细胞穿透的蛋白酶 C (protein kinase C) 和 促分裂原活化蛋白激酶 (MAPK) 抑制剂,能够抑制 PKC 活性,IC50 值为 660 nM。
  • HY-10578
    PD 169316 Inhibitor
    PD 169316 是一种高效,细胞透过的,有选择性的 p38 MAP kinase 抑制剂,IC50 值为 89 nM。
  • HY-10406
    SCIO-469 Inhibitor 98.07%
    SCIO-469是p38选择性的ATP竞争抑制剂,IC50值是9 nM.
  • HY-10328
    VX-745 Inhibitor 98.74%
    VX-745 是有效的,有选择性的 p38α 抑制剂,具有抗炎活性。
  • HY-11068
    SB 239063 Inhibitor 99.53%
    SB 239063是p38 MAPK选择性抑制剂,对p38α的IC50为44 nM,比对ERK,JNK1和其它激酶的抑制性高220倍。
  • HY-10401
    VX-702 Inhibitor 99.54%
    VX-702是p38αMAPK选择性抑制剂,IC50为4到20 nM。
  • HY-10456
    TAK-715 Inhibitor 99.93%
    TAK-715是p38 MAPK选择性抑制剂,IC50为7.1 nM,对p38γ/δ,JNK1,ERK1,IKKβ,MEKK1和TAK1无抑制性。
  • HY-15027
    5-Aminosalicylic acid Inhibitor >98.0%
    5-Aminosalicylic acid是抗炎化合物。
  • HY-14975
    R1487 Hydrochloride Inhibitor 98.68%
    R1487 (Hydrochloride)是一个强的和高的选择性的p38α抑制剂。
  • HY-14305A
    BMS-582949 hydrochloride Inhibitor 98.83%
    BMS-582949盐酸盐是一种新型的选择性p38α MAPK抑制剂, IC50值为13 nM。
  • HY-18306
    SB 242235 Inhibitor 99.63%
    SB-242235是p38 MAP激酶抑制剂,IC50为1.0 uM。
  • HY-10403
    PH-797804 Inhibitor 98.20%
    PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.
  • HY-10405
    Pamapimod Inhibitor 99.86%
    Pamapimod是一种有效的p38增殖蛋白激酶抑制剂。Pamapimod可以抑制p38α和p38β的酶活性,IC50值分别为0.014±0.002和0.48±0.04μM。Pamapimod 也能以IC50为0.06μm的效果抑制THP-1细胞的p38活性。