1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

p38 MAPK (p38 mitogen-activated protein kinase) is a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, andosmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAPK is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAPK, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12/ERK6), and -δ (MAPK13/SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), ultraviolet light, and growth factors.

p38 MAPK 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580 是一种 p38 MAPK 抑制剂,IC50 为 0.3-0.5 μM,也抑制 PKB 磷酸化,IC50 为 3-5 μM。
  • HY-10295
    SB 202190 Inhibitor 99.88%
    SB 202190 抑制 p38p38β2IC50 分别为 50 nM 和 100 nM。
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB203580(RWJ 64809)是p38 MAPK抑制剂,IC50为300-500nM。
  • HY-13241
    LY2228820 Inhibitor 99.94%
    LY2228820 是一种新颖的,有效的 p38 MAPK 抑制剂,IC50 值为 7 nM,但是不会改变 p38 MAPK 的活化。
  • HY-10320
    Doramapimod Inhibitor 99.40%
    Doramapimod 是一种高效的 p38α 抑制剂,IC50 为 4 nM,也抑制 B-Raf 和 Abl,IC50 分别为 83 nM 和 14.6 μM。
  • HY-10403
    PH-797804 Inhibitor
    PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.
  • HY-12048
    Chelerythrine Chloride Inhibitor >98.0%
    Chelerythrine Chloride 是一种有效的,细胞穿透的蛋白酶 C (protein kinase C) 和 促分裂原活化蛋白激酶 (MAPK) 抑制剂,能够抑制 PKC 活性,IC50 值为 660 nM。
  • HY-10402
    Losmapimod Inhibitor
    Losmapimod 是一种有效的,选择性的,可口服的 p38 MAPK 抑制剂,对 38α 和 p38β 的 pKi 值分别为 8.1 和 7.6。
  • HY-10578
    PD 169316 Inhibitor
    PD 169316 是一种高效,细胞透过的,有选择性的 p38 MAP kinase 抑制剂,IC50 值为 89 nM。
  • HY-100343
    GNE-495 Inhibitor 98.79%
    GNE-495是一个强的,有选择性的MAP4K4 抑制剂,IC50是3.7 nM。
  • HY-10328
    VX-745 Inhibitor 98.74%
    VX-745 是有效的,有选择性的 p38α 抑制剂,具有抗炎活性。
  • HY-10401
    VX-702 Inhibitor 99.54%
    VX-702是p38αMAPK选择性抑制剂,IC50为4到20 nM。
  • HY-11068
    SB 239063 Inhibitor 99.32%
    SB 239063是p38 MAPK选择性抑制剂,对p38α的IC50为44 nM,比对ERK,JNK1和其它激酶的抑制性高220倍。
  • HY-10456
    TAK-715 Inhibitor 99.97%
    TAK-715是p38 MAPK选择性抑制剂,IC50为7.1 nM,对p38γ/δ,JNK1,ERK1,IKKβ,MEKK1和TAK1无抑制性。
  • HY-10406
    SCIO-469 Inhibitor 98.07%
    SCIO-469是p38选择性的ATP竞争抑制剂,IC50值是9 nM.
  • HY-18306
    SB 242235 Inhibitor 99.63%
    SB-242235是p38 MAP激酶抑制剂,IC50为1.0 uM。
  • HY-14975
    R1487 Hydrochloride Inhibitor 98.68%
    R1487 (Hydrochloride)是一个强的和高的选择性的p38α抑制剂。
  • HY-100114
    TA-01 Inhibitor
    TA-01 有效抑制CK1ε, CK1δ,和p38α (IC50分别为 6.4, 6.8, 和 6.7 nM)。
  • HY-12839
    p38 MAPK-IN-1 Inhibitor 99.90%
    p38 MAPK-IN-1是p38 MAPK新型高效选择性抑制剂, IC50值68nM。
  • HY-15300
    Skepinone-L Inhibitor 98.99%
    Skepinone-L是选择性p38 MAPK抑制剂。