1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP). It is well known that p38 is involved in inflammation, apoptosis, cardiomyocyte hypertrophy and cell differentiation.

The p38 MAPK family is composed of four proteins: p38α (encoded by the gene Mapk14), p38β (Mapk11), p38γ (Mapk12), and p38δ (Mapk13). Their coding genes have a distinct tissue distribution and they appear differentially expressed, being Mapk14 the most highly expressed. p38 MAPKs are substrates for three MAP2K (MKK6, MKK3, and MKK4). The contribution of each of these MAP2K to p38 MAPKs activation depends on the stimulus and the cell type. The MAP3Ks that lead to p38 MAPKs activation are ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1.

p38 MAPK 相关产品 (37):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580是一种广泛使用的 p38 MAPK 抑制剂, IC50 介于 0.3-0.5μM 之间。 对 p38 MAPK 的选择性比 PKB, LCK, 和 GSK-3β 高100倍。
  • HY-10295
    SB 202190 Inhibitor 99.12%
    SB 202190 是可渗透细胞的 p38 MAPK 抑制剂,抑制p38 和 p38β2的 IC50 分别为50 nM 和 100 nM。
  • HY-10320
    Doramapimod Inhibitor 99.72%
    Doramapimod 是一种高效的 p38α 抑制剂,IC50 为 4 nM,也抑制 B-Raf 和 Abl,IC50 分别为 83 nM 和 14.6 μM。
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB 203580 hydrochloride是一种广泛使用的 p38 MAPK 抑制剂, IC50 介于 0.3-0.5 μM 之间。 对 p38 MAPK 的选择性比 PKB, LCK, 和 GSK-3β高100倍。
  • HY-13241
    LY2228820 Inhibitor 99.98%
    LY2228820是一种选择性,ATP竞争性的 p38 MAPK α/β 抑制剂,IC50 分别为5.3 和 3.2 nM。
  • HY-16782
    Pexmetinib Inhibitor 98.30%
    Pexmetinib 是一种有效的 Tie-2p38 MAPK 双重抑制剂,对 Tie-2,p38α 和 p38β 的 IC50 值分别为 1 nM,35 nM 和 26 nM,可用于急性骨髓性白血病的研究。
  • HY-112182
    UM-164 Inhibitor 99.08%
    UM-164 是一种高效的 c-Src 抑制剂,Kd 为 2.7 nM。UM-164 还高效抑制 p38αp38β 活性。
  • HY-103672
    AZD7624 Inhibitor
    AZD7624 是一种可吸入的 p38 抑制剂,具有高效的抗炎活性。
  • HY-11068
    SB 239063 Inhibitor 99.53%
    SB 239063是p38 MAPK选择性抑制剂,对p38α的IC50为44 nM,比对ERK,JNK1和其它激酶的抑制性高220倍。
  • HY-10402
    Losmapimod Inhibitor
    Losmapimod 是一种有效,选择性,可口服的 p38 MAPK 抑制剂,抑制p38α 和 p38β 的 pKi 值分别为 8.1 和 7.6。
  • HY-10578
    PD 169316 Inhibitor 98.33%
    PD 169316 是一种高效,细胞透过的,有选择性的 p38 MAP kinase 抑制剂,IC50 值为 89 nM。
  • HY-P0117
    Tat-NR2B9c Inhibitor 98.22%
    Tat-NR2B9c 是由 20 个氨基酸组成的多肽,为 PSD-95 的抑制剂,对 PSD-95d2 和 PSD-95d1 的 EC50 值分别为 6.7 nM 和 670 nM;Tat-NR2B9c 同时可降低 NMDA 诱导的 p38 的活化,具有神经保护作用。
  • HY-10406
    SCIO-469 Inhibitor 98.07%
    SCIO-469是p38选择性的ATP竞争抑制剂,IC50值是9 nM.
  • HY-N0674A
    Dehydrocorydaline chloride Activator 99.95%
    Dehydrocorydaline chloride 是一种天然生物碱类物质,具有抗炎、抗癌等功效。Dehydrocorydaline chloride 能够增强 p38 MAPK 的活化。
  • HY-10456
    TAK-715 Inhibitor 99.93%
    TAK-715是p38 MAPK选择性抑制剂,IC50为7.1 nM,对p38γ/δ,JNK1,ERK1,IKKβ,MEKK1和TAK1无抑制性。
  • HY-10328
    VX-745 Inhibitor 98.74%
    VX-745 是有效的,有选择性的 p38α 抑制剂,具有抗炎活性。
  • HY-10401
    VX-702 Inhibitor 99.54%
    VX-702是p38αMAPK选择性抑制剂,IC50为4到20 nM。
  • HY-10403
    PH-797804 Inhibitor 98.59%
    PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.
  • HY-12511
    SKF-86002 Inhibitor 99.51%
    SKF-86002是p38MAPK抑制剂,IC50值为0.5-1uM。
  • HY-14975
    R1487 Hydrochloride Inhibitor 98.68%
    R1487 (Hydrochloride)是一个强的和高的选择性的p38α抑制剂。
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