2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. Sodium Channel Adrenergic Receptor Potassium Channel
  4. Propafenone

Propafenone  (Synonyms: SA-79)

目录号: HY-B0432 纯度: 99.93%
COA 产品使用指南

摩尔计算器

Propafenone (SA-79) 是一种钠通道 (sodium-channel) 阻滞剂，具有抗心律失常的作用。Propafenone 对 β 受体也具有高亲和力 (IC50=32 nM)。Propafenone 阻断瞬时外向钾电流 (Ito) 和持续延迟整流器 K+ 电流 (Isus)，IC50 值分别为 4.9 μM 和 8.6 μM。Propafenone 通过诱导线粒体功能障碍和诱导细胞凋亡 (apoptosis) 抑制食管癌增殖。

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Propafenone Chemical Structure

Propafenone Chemical Structure

CAS No. : 54063-53-5

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550
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25 mg ￥500
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50 mg ￥800
In-stock
100 mg ￥1300
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Customer Review

Other Forms of Propafenone:

Propafenone 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM)[1]. Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively[2]. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis[3].

体外研究
(In Vitro)

Propafenone (5-25 μM) inhibits esophageal squamous cell carcinoma (ESCC) cell proliferation[3].
Propafenone causes mitochondrial dysfunction by a decreased mitochondrial membrane potential and reduced expression of Bcl-xL and Bcl-2[3].
Propafenone (10 and 20 μm) treatment significantly down regulates the expression levels of the anti-apoptotic proteins Bcl-xL and Bcl-2 in ESCC cells. Propafenone also reduces expression of p-ERK[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Propafenone 相关抗体:

Cell Proliferation Assay[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 5, 10, 15, 20, and 25 μm
Incubation Time: 24, 48, and 72 hours
Result: Gradually decreased cell proliferation over time and potently inhibited cell proliferation with increasing concentrations in KYSE30, KYSE150 and KYSE270 cells.

Western Blot Analysis[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 0, 10, and 20 μm
Incubation Time: 72 hours
Result: Significant downregulation of Bcl-xL and Bcl-2 expression levels was observed.
体内研究
(In Vivo)

Propafenone (20 mg/kg; intraperitoneal injection every other day) markedly suppresses the tumor burden with a decrease of 69.2%[3].
Propafenone also significantly inhibits tumor cell proliferation (mean index decreased from 56.3±6.7% in the DMSO-treated group to 20.7±5.1% in the 10 mg/kg propafenone-treated group and 11.3±4.0% in the 20 mg/kg propafenone-treated group)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice bearing KYSE270-derived xenografts (6-8 weeks)[3]
Dosage: 10 mg/kg or 20 mg/kg
Administration: Intraperitoneally injected
Result: Exerted a significantly inhibitory effect on the growth of tumor xenografts.
Clinical Trial
分子量

341.44

Formula

C21H27NO3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (366.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9288 mL 14.6439 mL 29.2877 mL
5 mM 0.5858 mL 2.9288 mL 5.8575 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.93%

COA (194 KB) HNMR (279 KB) LCMS (87 KB)

产品使用指南 (1538 KB)
参考文献

Propafenone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9288 mL 14.6439 mL 29.2877 mL 73.2193 mL
5 mM 0.5858 mL 2.9288 mL 5.8575 mL 14.6439 mL
10 mM 0.2929 mL 1.4644 mL 2.9288 mL 7.3219 mL
15 mM 0.1953 mL 0.9763 mL 1.9525 mL 4.8813 mL
20 mM 0.1464 mL 0.7322 mL 1.4644 mL 3.6610 mL
25 mM 0.1172 mL 0.5858 mL 1.1715 mL 2.9288 mL
30 mM 0.0976 mL 0.4881 mL 0.9763 mL 2.4406 mL
40 mM 0.0732 mL 0.3661 mL 0.7322 mL 1.8305 mL
50 mM 0.0586 mL 0.2929 mL 0.5858 mL 1.4644 mL
60 mM 0.0488 mL 0.2441 mL 0.4881 mL 1.2203 mL
80 mM 0.0366 mL 0.1830 mL 0.3661 mL 0.9152 mL
100 mM 0.0293 mL 0.1464 mL 0.2929 mL 0.7322 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propafenone54063-53-5SA-79SA79SA 79Sodium ChannelAdrenergic ReceptorPotassium ChannelNa channelsNa+ channelsBeta ReceptorKcsADrug repositioningapoptosismitochondria dysfunctionESCCsodium-channel blockerantiarrhythmic agentbeta receptorItoIsusesophagealmitochondrial dysfunctionInhibitorinhibitorinhibit

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