1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. Dopamine Receptor 5-HT Receptor Potassium Channel
  3. SCH-23390 maleate

SCH-23390 maleate  (Synonyms: R-(+)-SCH-23390 maleate)

目录号: HY-108400
产品使用指南

SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是一种有效的选择性的多巴胺 D1 样受体拮抗剂,其对 D1D5 受体的 Ki 分别为 0.2 nM 和 0.3 nM。SCH-23390 maleate 也是一种有效的人 5-HT2C 受体激动剂,Ki 为 9.3 nM。SCH-23390 maleate 与 5-HT25-HT1C 受体具有高亲和力。SCH-23390 maleate 还抑制 G 蛋白偶联的内向整流钾 (GIRK) 通道,IC50 为 268 nM。

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SCH-23390 maleate Chemical Structure

SCH-23390 maleate Chemical Structure

CAS No. : 87134-87-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3].

IC50 & Target[1][2][3]

D1 Receptor

0.2 nM (Ki)

D5 Receptor

0.3 nM (Ki)

5-HT2C Receptor

9.3 nM (Ki)

GIRK

268 nM (IC50)

体外研究
(In Vitro)

SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

403.86

Formula

C21H22ClNO5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SCH-23390 maleate
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HY-108400
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