2. Protein Tyrosine Kinase/RTK Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. VEGFR Apoptosis Reactive Oxygen Species
  4. VEGFR-2-IN-19

VEGFR-2-IN-19 (Compound 15b) 是一种有效的 VEGFR2 抑制剂。VEGFR-2-IN-19 诱导细胞凋亡 (apoptosis)，增加细胞内活性氧 (reactive oxygen species) 水平。VEGFR-2-IN-19 可以用作抗癌剂。

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VEGFR-2-IN-19 Chemical Structure

VEGFR-2-IN-19 Chemical Structure

CAS No. : 2456315-41-4

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VEGFR-2-IN-19 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-19 (Compound 15b) is a potent VEGFR2 inhibitor. VEGFR-2-IN-19 induces cell apoptosis and increases intracellular reactive oxygen species level. VEGFR-2-IN-19 can be used as an anticancer agent[1].

IC50 & Target

VEGFR2

 

体外研究
(In Vitro)

VEGFR-2-IN-19 (Compound 15b) (0-100 µM, 48 h) shows antiproliferative activity against cancer cells[1].
VEGFR-2-IN-19 (0-10 µM, 48 h) inhibits the phosphorylation of VEGFR2 and the Raf/MEK/ERK signaling pathway, induces cell apoptosis, and arrests cell cycle at G0/G1 phase in HT-29 cells[1].
VEGFR-2-IN-19 (0-10 µM, 12 h) increases intracellular reactive oxygen species level in HT-29 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-19 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HT-29 and A549
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50 values of 3.38±1.3 µM and 0.63±0.04 µM against HT-29 and A549 cells, respectively.

Western Blot Analysis[1]

Cell Line: HT-29
Concentration: 0, 1, 5, and 10 µM
Incubation Time: 48 h
Result: Effectively inhibited the phosphorylation of VEGFR2 in dose-dependent manner. Suppressed dose-dependently expression of c-Raf, ERK1/2, and MEK and phosphorylation of ERK1/2 (pERK1/2). Up-regulated caspase-3 and Bax expression, down-regulated Bcl-2 expression.

Apoptosis Analysis[1]

Cell Line: HT-29
Concentration: 0, 1, 5, and 10 µM
Incubation Time: 48 h
Result: The total numbers of early and late apoptotic cells were increased significantly relative to that of untreated control cells in dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HT-29
Concentration: 0, 1, 5, and 10 µM
Incubation Time: 48 h
Result: Increased the population of cells in sub G1 and G0/G1 phase and decreased the population of cells in S phase.
分子量

345.39

Formula

C21H19N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2-IN-19 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-192456315-41-4VEGFRApoptosisReactive Oxygen SpeciesVascular endothelial growth factor receptorHT-29A549Raf/MEK/ERK signaling pathwayanticancerInhibitorinhibitorinhibit

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