1. Protein Tyrosine Kinase/RTK Apoptosis
  2. VEGFR Apoptosis MDM-2/p53
  3. VEGFR-2-IN-23

VEGFR-2-IN-23 (compound 11b) 是一种有效的选择性 VEGFR-2 抑制剂,IC50 值为 0.34 nM。VEGFR-2-IN-23 显示出抗肿瘤活性。VEGFR-2-IN-23 诱导细胞凋亡 (apoptosis) 和 MCF-7 细胞停滞在 G1 期。

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VEGFR-2-IN-23 Chemical Structure

VEGFR-2-IN-23 Chemical Structure

CAS No. : 2411174-53-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

IC50 & Target[1]

VEGFR-2

0.19 nM (IC50)

体外研究
(In Vitro)

VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC50s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

381.39

Formula

C22H15N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
VEGFR-2-IN-23
目录号:
HY-149024
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