1. GPCR/G Protein
  2. MCHR1 (GPR24)

MCHR1 (GPR24)

MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, belongs to a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone, and is one of the melanin-concentrating hormone receptors found in all mammals. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. MCHR1 is thought to regulate appetite, and also functions in stress, anxiety and depression.

MCHR1 (GPR24) 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-12433
    BMS-819881 Antagonist
    BMS-819881 是一种黑色素浓缩激素受体1 (MCHR1) 拮抗剂,结合大鼠 MCHR1,Ki 值为 7 nM。BMS-819881 还有效且选择性地作用于 CYP3A4EC50 为 13 μM.
  • HY-100318
    NGD-4715 Antagonist
    NGD-4715是选择性,有口服活性的黑色素浓缩激素受体1 (melanin-concentrating hormone receptor 1 (MCHR1)) 的拮抗剂。
  • HY-111398
    ALB-127158(a) Antagonist 99.32%
    ALB-127158(a) 是一种有效的选择性黑色素浓缩激素 1 (MCH1) 受体拮抗剂。
  • HY-100321
    MCHr1 antagonist 2 Antagonist
    MCHr1 antagonist 2 是一种黑色素聚集激素受体 1 (melanin concentrating hormone receptor 1) 拮抗剂,IC50 值为 65 nM;MCHr1 antagonist 2 同时抑制 hERG,在 IMR-32 细胞中,IC50 值为 4.0 nM。
  • HY-100331
    MCH-1 antagonist 1 Antagonist
    MCH-1 antagonist 1 是一种有效的黑色素浓缩激素 1 (MCH-1) 拮抗剂,Ki 值为 2.6 nM。MCH-1 antagonist 1 还抑制 CYP3A4IC50 为 10 μM。
  • HY-100308
    SB-568849 Antagonist
    SB-568849 是一种黑色素浓缩激素受体 1 (MCH R1) 拮抗剂,pKi 值为 7.7。
  • HY-P1525
    Melanin Concentrating Hormone, salmon Agonist
    Melanin Concentrating Hormone, salmon是最初在硬骨鱼的垂体中发现的19个氨基酸组成的神经肽,它调节食物摄入,能量平衡,睡眠状态和心血管系统。 Melanin-concentrating hormone是 SLC-1/GPR24 MCHR2 的配体。
  • HY-U00353
    MCHr1 antagonist 1 Antagonist
    MCHr1 antagonist 1 是一种选择性的黑色素浓集激素 1 型受体 (melanin concentrating hormone-1 receptor) 拮抗剂,对人 MCH1 受体 的 KbKi 值分别为 1 nM 和 4 nM,在降低体重方面可能起作用。
  • HY-U00257
    AZD1979 Antagonist
    AZD1979 是一个 Melanin-concentrating hormone receptor 1 (MCHr1) 拮抗剂, 其 IC50 值约为 12 nM。
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