2. Gene
  3. Cdk6 - cyclin-dependent kinase 6 Gene

Cdk6 - cyclin-dependent kinase 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 6

种属: Rattus norvegicus

基因 ID: 114483 | 基因类型: protein coding

关于 Cdk6

Primary_assembly 4: 30,646,460-30,829,634 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 199 orthologues, 24 paralogues and is associated with 24 phenotypes. Biased expression in Thymus (RPKM 15.7), Kidney (RPKM 87.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动细胞周期蛋白结合活性。预计参与多个过程，包括细胞衰老的负调控；成骨细胞分化的负调节；和骨髓细胞分化的调节。预计在几个过程的上游或内部起作用，包括造血；基因表达的调节；和造血干细胞分化的调控。预计位于几个细胞成分中，包括中心体；核质；和荷叶边。预计是细胞周期蛋白 D2-CDK6 复合物和介体复合物的一部分。预计活跃于核心。该基因的人类直系同源物与高级别神经胶质瘤有关；肺非小细胞癌；胰腺癌；胰腺导管癌；和原发性常染色体隐性小头畸形 12。与人类 CDK6（细胞周期蛋白依赖性激酶 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclin binding activity. Predicted to be involved in several processes, including negative regulation of cellular senescence; negative regulation of osteoblast differentiation; and regulation of myeloid cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of hematopoietic stem cell differentiation. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D2-CDK6 complex and mediator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Cdk6 基因产物(1)

mRNA Protein Name
NM_001191861.2 NP_001178790.1 cyclin-dependent kinase 6

Cdk6 蛋白结构

STKc_CDK6

STKc_CDK6: cd07862 (10 - 299)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 6

cell division protein kinase 6

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50767 Palbociclib Inhibitor 99.94% 否
HY-16297A Abemaciclib Inhibitor 99.96% 是
HY-15777 Ribociclib Inhibitor 99.98% 否
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% 否
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
HY-A0065 Palbociclib isethionate Inhibitor 99.99% 否
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% 否
HY-15777B Ribociclib succinate Inhibitor 99.93% 否
HY-50767C Palbociclib hydrochloride Inhibitor 99.84% 否
HY-101467A Trilaciclib hydrochloride Inhibitor 99.74% 否
HY-15777C Ribociclib succinate hydrate Inhibitor 99.96% 否
HY-50767D Palbociclib orotate Inhibitor / 否
HY-50767B Palbociclib dihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (19)
目录号 产品名 作用方式
纯度 Phase
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.92% Phase 3
HY-114338 Dalpiciclib Inhibitor 99.40% Phase 3
HY-101563 GSK3326595 99.97% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-12624 Narazaciclib Inhibitor 99.12% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-16559 Riviciclib hydrochloride 99.01% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
生物活性分子 (57)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103248 Toyocamycin Inhibitor 99.90% 否
HY-139450 PF-07220060 Inhibitor 99.87% 否
HY-10329 JNJ-7706621 Inhibitor 99.91% 否
HY-111556 BSJ-03-123 Inhibitor 98.12% 否
HY-136250 BSJ-03-204 Inhibitor 99.76% 否
HY-114177 Ebvaciclib Inhibitor 99.98% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-136252 BSJ-04-132 Inhibitor 98.32% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.80% 否
HY-138946 XY028-140 Inhibitor 98.42% 否
HY-12445 Asnuciclib Inhibitor 99.76% 否
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.94% 否
HY-116035 Nimbolide Inhibitor 99.94% 否
HY-125835 CP-10 Inhibitor 98.22% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-129336 Abemaciclib metabolite M20 Inhibitor 96.02% 否
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.01% 否
HY-50767S Palbociclib-d8 Inhibitor 99.84% 否
HY-129180 XY028-133 Inhibitor 98.62% 否
HY-15889 AMG 925 Inhibitor 98.20% 否
HY-148530 YX-2-107 Degrader 99.79% 否
HY-15241 NVP-LCQ195 Inhibitor 98.91% 否
HY-148062 RSS0680 98.03% 否
HY-126251 CDK9-IN-7 Inhibitor 98.05% 否
HY-112243A Cimpuciclib tosylate Inhibitor 99.16% 否
HY-148063 DB0614 98.80% 否
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% 否
HY-114339 CDK4/6-IN-2 Inhibitor 99.82% 否
HY-142076 CDK4/6-IN-15 Inhibitor 96.15% 否
HY-112346 RGB-286147 Inhibitor ≥98.0% 否
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 97.01% 否
HY-15889A AMG 925 HCl Inhibitor / 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-136726 CGP-82996 Inhibitor / 否
HY-112243 Cimpuciclib Inhibitor / 否
HY-131063 CDK6/9-IN-1 Inhibitor / 否
HY-103712 Samuraciclib Inhibitor / 否
HY-126244 CDK4/6-IN-3 Inhibitor / 否
HY-146213 CDK4/6-IN-12 Inhibitor / 否
HY-155787 SHR5428 Inhibitor / 否
HY-126534 Abemaciclib metabolite M18 Inhibitor / 否
HY-143258 CDK4/6-IN-8 Inhibitor / 否
HY-147409 Ulecaciclib Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-112418 CDK4/6-IN-18 Inhibitor / 否
HY-115942 Anticancer agent 29 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-148213 CDK2/4/6-IN-1 Inhibitor / 否
HY-115993 CDK4/6-IN-10 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-115992 CDK4/6-IN-9 Inhibitor / 否
HY-143257 CDK4/6-IN-7 Inhibitor / 否
HY-153336 CDK-IN-12 Inhibitor / 否
HY-151898 CDK4/6-IN-14 Inhibitor / 否
HY-148214 CDK2/4/6-IN-2 Inhibitor / 否
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor / 否
HY-153088 CDK4/6-IN-16 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk6 NCBI NCBI:1021
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