2. Gene
  3. Jak1 - Janus kinase 1 Gene

Jak1 - Janus kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：两面神激酶 1

种属: Mus musculus

同用名: BAP004; C130039L05Rik

基因 ID: 16451 | 基因类型: protein coding

关于 Jak1

Chromosome 4: 101,009,564-101,122,479 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 238 orthologues, 32 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thymus adult (RPKM 28.5), spleen adult (RPKM 26.3) and 28 other tissues.

功能概要

该基因编码的蛋白可启动生长激素受体结合活性和蛋白酪氨酸激酶活性。作用于多个过程的上游或内部，包括细胞表面受体信号通路；对细胞因子刺激的细胞反应；以及通过 STAT 对受体信号通路的正向调控。预测位于细胞质和细胞核中。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；淋巴系统腺体；以及肝脏和胆道系统。用于研究系统性红斑狼疮。与 T 细胞急性淋巴细胞白血病有关的该基因的人类直系同源物；结直肠癌；肝细胞癌；卵巢癌;和胰腺癌。与人类 JAK1（Janus 激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; colorectal cancer; hepatocellular carcinoma; ovarian cancer; and pancreatic adenocarcinoma. Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Jak1 基因产物(2)

mRNA Protein Name
NM_146145.2 NP_666257.2 tyrosine-protein kinase JAK1 isoform 1
NM_013567.1 NP_038595.1 tyrosine-protein kinase JAK1 isoform 2

Jak1 蛋白结构

FERM_F1

FERM_F1: cl39717 (51 - 128)

FERM_F2

FERM_F2: pfam18377 (146 - 276)

FERM_C_JAK1

FERM_C_JAK1: cd13332 (281 - 425)

SH2_Jak1

SH2_Jak1: cd10378 (425 - 525)

PTK_Jak1_rpt1

PTK_Jak1_rpt1: cd05077 (581 - 844)

PTKc_Jak1_rpt2

PTKc_Jak1_rpt2: cd05079 (868 - 1151)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1153 a.a.
蛋白主名 其他名称

tyrosine-protein kinase JAK1

JAK-1

相关产品

Approval
生物活性分子 (21)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50856 Ruxolitinib Inhibitor 99.99% 是
HY-40354 Tofacitinib Inhibitor 99.99% 是
HY-117287 Deucravacitinib Inhibitor 99.87% 是
HY-15315 Baricitinib Inhibitor 99.97% 是
HY-19569 Upadacitinib Inhibitor 99.98% 是
HY-50858 Ruxolitinib phosphate Inhibitor 99.98% 是
HY-16379 Pacritinib Inhibitor 99.93% 是
HY-40354A Tofacitinib citrate Inhibitor 99.98% 是
HY-18300 Filgotinib Inhibitor 99.68% 是
HY-107429 Abrocitinib Inhibitor 99.26% 否
HY-19568 Peficitinib Inhibitor 99.43% 是
HY-15315A Baricitinib phosphate Inhibitor 99.91% 是
HY-109053 Delgocitinib Inhibitor 99.87% 否
HY-13577A Oclacitinib maleate Inhibitor 99.63% 否
HY-13577 Oclacitinib Inhibitor 99.23% 否
HY-19568A Peficitinib hydrobromide Inhibitor / 否
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / 否
HY-18300A Filgotinib maleate Inhibitor / 否
HY-16379A Pacritinib hydrochloride Inhibitor / 否
HY-19568B Peficitinib hydrochloride Inhibitor / 否
HY-50859 Ruxolitinib sulfate Inhibitor / 否
Clinical Phase
生物活性分子 (21)
目录号 产品名 作用方式
纯度 Phase
HY-10961 Momelotinib Inhibitor 99.37% Phase 3
HY-16997 Itacitinib Inhibitor 99.97% Phase 3
HY-15999 Cerdulatinib Inhibitor 98.96% Phase 3
HY-12469 Decernotinib Inhibitor 99.67% Phase 3
HY-10962 Momelotinib sulfate Inhibitor 98.06% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.82% Phase 3
HY-16997A Itacitinib adipate Inhibitor 99.18% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-50856S Deuruxolitinib Inhibitor 99.18% Phase 3
HY-10963 Momelotinib Mesylate Inhibitor / Phase 3
HY-15270 BMS-911543 Inhibitor 98.53% Phase 2
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.86% Phase 2
HY-107361 Golidocitinib Inhibitor 99.75% Phase 2
HY-19631A Ilginatinib Inhibitor 99.94% Phase 2
HY-16755 Solcitinib Inhibitor 99.73% Phase 2
HY-112708 Brepocitinib Inhibitor 98.64% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor ≥98.0% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-10193 AZD-1480 Inhibitor 99.91% Phase 1
HY-126294 Londamocitinib Inhibitor 98.98% Phase 1
HY-101024 PF-06263276 Inhibitor 99.38% Phase 1
Pre-clinical Phase
生物活性分子 (46)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W063968 RO8191 Activator ≥99.0% 否
HY-14435 Pyridone 6 Inhibitor 98.13% 否
HY-100895 SAR-20347 Inhibitor 97.12% 否
HY-151385 VVD-118313 Inhibitor 99.75% 否
HY-14722 NVP-BSK805 Inhibitor 99.89% 否
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% 否
HY-12589 ZM39923 hydrochloride Inhibitor 98.19% 否
HY-151262 JAK-IN-23 Inhibitor 98.90% 否
HY-130247 JAK2/FLT3-IN-1 Inhibitor 99.79% 否
HY-131906 JAK2-IN-7 Inhibitor 99.15% 否
HY-130247A JAK2/FLT3-IN-1 TFA Inhibitor 99.77% 否
HY-108264 TCS 21311 Inhibitor 99.18% 否
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 98.78% 否
HY-139423 JAK1-IN-8 Inhibitor ≥95.0% 否
HY-13961 GLPG0634 analog Inhibitor 98.58% 否
HY-19544 JAK3-IN-1 Inhibitor 99.23% 否
HY-151385A (R,R)-VVD-118313 Inhibitor 99.54% 否
HY-116505 JAK1-IN-4 Inhibitor / 否
HY-111750 JAK-IN-3 Inhibitor 98.92% 否
HY-W394903 GS-829845 Inhibitor 99.91% 否
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / 否
HY-152080 TUL01101 Inhibitor / 否
HY-156409 ABBV-712 Inhibitor / 否
HY-108342 PF-00956980 Inhibitor / 否
HY-153440 JAK-IN-25 Inhibitor 98.44% 否
HY-139649 Ten01 Inhibitor / 否
HY-161259 JAK-IN-36 Inhibitor / 否
HY-144440 JAK1-IN-9 Inhibitor / 否
HY-100849 JAK 3i Inhibitor / 否
HY-149296 JAK1-IN-12 Inhibitor / 否
HY-147754 JAK3/BTK-IN-6 Inhibitor / 否
HY-162248 JAK1/2-IN-1 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-143444 JAK-IN-20 Inhibitor / 否
HY-161139 JAK1-IN-14 Inhibitor / 否
HY-150720 TYK2-IN-12 Inhibitor / 否
HY-157121 JAK-IN-34 Inhibitor / 否
HY-146727 JAK3-IN-11 Inhibitor / 否
HY-15814 HG-7-85-01 Inhibitor 99.94% 否
HY-147975 JAK3-IN-12 Inhibitor / 否
HY-153566 JAK1-IN-10 Inhibitor / 否
HY-143885 JAK1/TYK2-IN-3 Inhibitor / 否
HY-154994 JAK-IN-30 Inhibitor / 否
HY-161618 MJ04 Inhibitor / 否
HY-148060 JAK-IN-21 Inhibitor 99.72% 否
HY-12589A ZM39923 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Jak1 NCBI NCBI:3716
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z