Ghsr - growth hormone secretagogue receptor Gene

中文名称：生长激素促分泌素受体

种属: Mus musculus

同用名: GHRP; GHS-R; Ghsr1a; C530020I22Rik

关于 Ghsr

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联受体活性；相同的蛋白质结合活性；和肽激素结合活性。参与成虫的摄食行为和食欲的正向调节。作用于多个过程的上游或内部，包括细胞对胰岛素刺激的反应；生长激素分泌；胰岛素样生长因子受体信号通路的正调控。预测位于细胞表面；膜筏；和神经元投射。预计在质膜上有活性。以多种结构表达，包括中枢神经系统；泌尿生殖系统；淋巴系统腺体；和气管。该基因的人类直系同源物与肥胖有关。与人类 GHSR（生长激素促分泌素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity; identical protein binding activity; and peptide hormone binding activity. Involved in adult feeding behavior and positive regulation of appetite. Acts upstream of or within several processes, including cellular response to Insulin stimulus; growth hormone secretion; and positive regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cell surface; membrane raft; and neuron projection. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and trachea. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]