BCL2 - BCL2, apoptosis regulator Gene

中文名称：BCL2 ，细胞凋亡调节因子

种属: Rattus norvegicus

同用名: Bcl-2

关于 BCL2

功能概要

该基因编码的蛋白可启动 BH 域绑定活动。参与多个过程，包括对肽的反应；对含嘌呤化合物的反应；和对维生素的反应。位于胞质溶胶中；线粒体嵴；和细胞质的核周区。用于研究多种疾病，包括脑缺血（多种）；晚期肾脏疾病;胃溃疡;肠道疾病（多种）；和癫痫持续状态。几种疾病的生物标志物，包括腹型肥胖-代谢综合征 1；脑部疾病（多种）；高血压（多发性）；内在性心肌病（多发性）；和神经退行性疾病（多种）。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；血液系统癌症（多发性）；颅内动脉瘤;前列腺癌;和膀胱癌。与人 BCL2 同源（BCL2 细胞凋亡调节剂）。 [由基因组资源联盟提供，2022 年 4 月]

Enables BH domain binding activity. Involved in several processes, including response to peptide; response to purine-containing compound; and response to vitamin. Located in cytosol; mitochondrial crista; and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and status epilepticus. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain disease (multiple); hypertension (multiple); intrinsic cardiomyopathy (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic Cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder Cancer. Orthologous to human BCL2 (BCL2 Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]