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Aromatase

Aromatase (also known as CYP19) is a member of the general class of cytochrome P450 enzymes. It catalyzes the conversion of androgens to estrogens, which is a crucial step in the biosynthesis of estrogens in the human body.

Aromatase enzyme is expressed in ovarian granulosa cells, placental syncytiotrophoblast, adipose tissue, brain, and skin fibroblasts. The primary sources of aromatase are ovarian granulosa cells in premenopausal women and adipose cells in postmenopausal women. Aromatase inhibitors suppress oestrogen synthesis in the ovaries and in peripheral tissues, starting from the next day after dosing. They work by inhibiting the action of aromatase, which converts androgens into oestrogens (testosterone into estradiol and androstenedione into oestrone). There are three generations of aromatase inhibitors (AIs). Aminoglutethimide is a first-generation aromatase inhibitor. The second-generation inhibitors include Fadrozole and Formestane. Anastrozole, Letrozole, and Exemestane are third-generation inhibitors.

Aromatase is encoded by the cyp19a1 gene, belongs to a particular reticulum-bound cytochrome P450 superfamily and forms an electron-transfer complex with its partner, NADPH-cytochrome P450 reductase (CPR).

Aromatase 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-14248
    Letrozole Inhibitor 99.92%
    Letrozole是芳香酶抑制剂,其 IC50 为1-13 nM。
  • HY-14247
    Fadrozole hydrochloride Inhibitor 99.64%
    Fadrozole hydrochloride 是一种有效,选择性和非甾体类的 aromatase 抑制剂,其 IC50 值为 6.4 nM。
  • HY-13632
    Exemestane Inhibitor 99.95%
    Exemestane(FCE 24304)是芳香酶(aromatase)抑制剂,能抑制人胎盘和鼠卵巢芳香酶,IC50分别为30 nM和40 nM。
  • HY-14247A
    Fadrozole Inhibitor 99.78%
    Fadrozole是一种有效,选择性和非甾体类的 aromatase 抑制剂,IC50 值为6.4 nM。
  • HY-14274
    Anastrozole Inhibitor 99.93%
    Anastrozole 是一种选择性的芳香酶 (aromatase) 抑制剂,抑制胎盘芳香化酶,IC50 为 15 nM。
  • HY-N0292
    Oleuropein Inhibitor 98.54%
    Oleuropein 在橄榄叶和油中发现的,可通过直接抑制 PPARγ 转录活性来发挥抗氧化,抗炎和抗动脉粥样硬化作用。Oleuropein 通过 p53 依赖性途径以及 BaxBcl2 基因的调控来诱导乳腺癌细胞凋亡。Oleuropein 还抑制芳香化酶 (aromatase)。
  • HY-18719E
    Endoxifen
    Endoxifen 是tamoxifen 的关键活性代谢物,与雌激素受体 (estrogen receptor) 有较高的亲和力和特异性,同时也能抑制芳香酶的活性。
  • HY-125833
    Alpha-Naphthoflavone Inhibitor 98.02%
    Alpha-Naphthoflavone 是一种合成的黄酮类化合物,为有效、竞争性的芳香酶 aromatase 抑制剂,IC50Ki 值分别为 0.5 和 0.2 μM。
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