1. Signaling Pathways
  2. Immunology/Inflammation
  3. CD73

CD73 (胞外-5′-核苷酸酶)

CD73 (Ecto-5′-nucleotidase) is a 70-kD glycosylphosphatidyl inositol (GPI)-anchored cell surface protein encoded by the NT5E gene that plays a crucial role in switching on adenosinergic signaling. CD73 is an ectonucleotidase which catalyzes the terminal step in extracellular adenine nucleotide breakdown: the conversion of AMP to adenosine. Adenosine, which binds to a discrete family of cell surface receptors to initiate intracellular signaling cascades, has been shown to be anti-inflammatory and vasorelaxant.

CD73 has both enzymatic and non-enzymatic functions in cells: as a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape; moreover, CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other. There is ample evidence to show that CD73 is a key regulatory molecule in cancer development and is overexpressed in many cancers, including leukemia, glioblastoma, melanoma, ovarian cancer, esophageal cancer, prostate cancer and breast cancer.

CD73 相关产品 (16):

目录号 产品名 作用方式 纯度
  • HY-125286
    AB-680 Inhibitor 99.71%
    AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂,对 hCD73 的 Ki 值为 4.9 pM,对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。
  • HY-100747
    PSB-12379 Inhibitor ≥98.0%
    PSB-12379 是一种核苷酸类似物,是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂,Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
  • HY-103695
    CD73-IN-1 Inhibitor 98.54%
    CD73-IN-1 是 CD73 的抑制剂,可用于癌症的研究,来自专利 WO 2017153952 A1, 实例 80。
  • HY-136978
    OP-5244 Inhibitor 99.63%
    OP-5244 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
  • HY-137246
    CD73-IN-3 Inhibitor ≥98.0%
    CD73-IN-3 是一种有效的 CD73 抑制剂(IC50; Calu6 人细胞实验中)。CD73-IN-3,例 2 源自专利 WO2019168744 A1,具有研究癌症的潜力。
  • HY-145334
    CD73-IN-5 Inhibitor
    CD73-IN-5 是一种有效且选择性的非核苷酸小分子 CD73 抑制剂(IC50 = 19 nM)。
  • HY-P99039
    Oleclumab

    奥来鲁单抗; 奥来珠单抗

    Inhibitor
    Oleclumab (MEDI9447) 是一种人 IgG1λ 抗 CD73 单克隆抗体,可抑制 CD73 功能。Oleclumab 具有抗肿瘤活性。
  • HY-144209
    CD73-IN-6 Inhibitor
    CD73-IN-6 是一种 CD73 抑制剂,可用于癌症研究,详细信息请参考专利文献 WO2022007677A1 中的化合物 2。
  • HY-131967
    CD73-IN-4 Inhibitor 99.54%
    CD73-IN-4 是一种高效、选择性的亚甲基膦酸 CD73 抑制剂,对人 CD73 作用的 IC50 值为 2.6 nM。CD73-IN-4 在癌症免疫学研究中具有潜在的应用价值。
  • HY-136978A
    OP-5244 sodium Inhibitor
    OP-5244 sodium 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 sodium 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
  • HY-125286A
    AB-680 ammonium Inhibitor
    AB-680 ammonium 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂,对 hCD73 的 Ki 值为 4.9 pM,对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。
  • HY-112502B
    MethADP sodium salt Inhibitor
    MethADP (sodium salt) 是一个特异性的 CD73 抑制剂。
  • HY-100747A
    PSB-12379 disodium Inhibitor
    PSB-12379 disodium 是一种核苷类似物,是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂,Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
  • HY-144072
    MRS4620 Inhibitor
    MRS4620 是一种有效的 CD73 抑制剂,Ki 值为 0.436 nM。MRS4620 可用于癌症免疫治疗的研究。
  • HY-131435
    CD73-IN-2 Inhibitor
    CD73-IN-2 是一种有效的 CD73 抑制剂,IC50 为 0.09 nM,详细信息请参考专利 WO2020151707A1,example 1。
  • HY-112502
    MethADP Inhibitor
    MethADP 是一个特异性的 CD73 抑制剂。
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