1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. MELK

MELK (母体胚胎亮氨酸拉链激酶)

MELK (Maternal embryonic leucine zipper kinase) belongs to the CAMK serine/threonine protein kinase superfamily. Melk is a protein serine/threonine kinase that is maximally active during mitosis. It is involved in diverse functions such as cell cycle, cytokinesis, mRNA splicing and apoptosis. Expression MELK is expressed in cells of various tissue origins. MELK expression is strongly dependant on cell-cycle: MELK is undetectable in cells which have exited cell cycle. The exact function of MELK is currently unknown, however MELK was shown to be involved in cell cycle progression via the protein phosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis via its interaction with the Bcl-2 family of proapoptotic genes and apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association with NIPP1. MELK function is required for mammary tumorigenesis in vivo.

MELK 相关产品 (5):

目录号 产品名 作用方式 纯度
  • HY-15512A
    OTSSP167 hydrochloride Inhibitor 99.84%
    OTSSP167 hydrochloride 是一种高效的,ATP 竞争性的 MELK 抑制剂,IC50 值为 0.41 nM。
  • HY-100368A
    MELK-8a hydrochloride Inhibitor 98.46%
    MELK-8a hydrochloride是一种新颖的母体胚胎亮氨酸拉链激酶(MELK)抑制剂,其IC50值为2 nM。
  • HY-12420
    JNJ-47117096 hydrochloride Inhibitor 98.01%
    JNJ-47117096 hydrochloride 是一种有效的,选择性的 MELK 抑制剂,IC50 值为 23 nM;同时对 Flt3 的作用较强,IC50 值为 18 nM。
  • HY-15512
    OTSSP167 Inhibitor
    OTSSP167 是一种高效的,ATP 竞争性的 MELK 抑制剂,IC50 值为 0.41 nM。
  • HY-101515
    MELK-IN-1 Inhibitor
    MELK-IN-1是母体胚胎亮氨酸拉链激酶 (MELK)的有效抑制剂,IC50Ki 分别为3 nM和0.39 nM。
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