2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Angiopoietins

Angiopoietins  (血管生成素家族)

血管生成素是一类血管生长因子家族，与TIE (带有Ig和表皮生长因子同源域的Tyr激酶) 受体结合。ANG1, ANG2和ANG4 (小鼠ANG3的人类同源物) 是TIE2的配体，而TIE1仍然是一种孤儿受体，能够与TIE2 形成异质二聚体并调节TIE2信号转导。Ang/Tie 通路在调节血管稳定、生理和病理条件下的血管生成，以及炎症中发挥重要作用。在生理条件下，ANG1 与结合并磷酸化TIE2 受体，引起促进细胞存活和血管稳定的下游信号。ANG2在病理条件下上调，并作为Ang-1/Tie2轴的上下关联依赖性激动剂/拮抗剂，导致血管不稳定，并使血管对血管内皮生长因子 VEGF-A 敏感。

Angiopoietins are a family of vascular growth factors that bind to TIE (Tyr kinase with Ig and epidermal growth factor homology domains) receptors. The growth factors ANG1, ANG2 and ANG4 (the human orthologue of mouse ANG3) are ligands for TIE2, whereas TIE1 remains an orphan receptor which is able to heterodimerize with TIE2 and to modulate TIE2 signal transduction. The Ang/Tie pathway plays an important role in the regulation of vascular stability, in angiogenesis under physiological and pathological conditions, as well as in inflammation. Under physiological conditions, ANG1 binds to and phosphorylates the TIE2 receptor, leading to downstream signalling that promotes cell survival and vascular stability. ANG2 is upregulated under pathological conditions and acts as a context-dependent agonist/antagonist of the Ang-1/Tie2 axis, causing vascular destabilisation and sensitising blood vessels to the effects of vascular endothelial growth factor-A (VEGF-A).

 
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