1. Signaling Pathways
  2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)

Glucosylceramide Synthase (GCS) (葡萄糖神经酰胺合成酶)

Glucosylceramide synthase (GCS), converting ceramide to glucosylceramide, catalyzes the first reaction of ceramide glycosylation in sphingolipid metabolism. This glycosylation by GCS is a critical step regulating the modulation of cellular activities by controlling ceramide and glycosphingolipids (GSLs). An increase of ceramide in response to stresses, such as chemotherapy, drives cells to proliferation arrest and apoptosis or autophagy; however, ceramide glycosylation promptly eliminates ceramide and consequently, these induced processes, thus protecting cancer cells. Furthermore, persistently enhanced ceramide glycosylation can increase GSLs, participating in selecting cancer cells to drug resistance. GCS is overexpressed in diverse drug-resistant cancer cells and in tumors of breast, colon, and leukemia that display poor response to chemotherapy. As ceramide glycosylation by GCS is a rate-limiting step in GSL synthesis, inhibition of GCS sensitizes cancer cells to anticancer drugs and eradicates cancer stem cells.

Glucosylceramide Synthase (GCS) 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-16743
    Ibiglustat 99.81%
    Ibiglustat (Venglustat) 是一种具有口服活性的,可透过血脑屏障的葡萄糖神经酰胺合成酶 (GCS) 抑制剂。Ibiglustat 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。
  • HY-17020A
    Miglustat hydrochloride

    盐酸美格鲁特

    Inhibitor 98.20%
    Miglustat (N-Butyldeoxynojirimycin) hydrochloride 是一种神经酰胺葡糖基转移酶抑制剂,具有口服活性。Miglustat hydrochloride 可用于 I 型戈谢病的研究。
  • HY-106392
    Lucerastat 98.20%
    Lucerasta 是Miglustat 的半乳糖形式,是具有口服活性的葡萄糖酰神经酰胺合成酶 (GCS) 的抑制剂。Lucerastat 有用于Fabry 疾病研究的潜能。
  • HY-16743A
    Ibiglustat (L-Malic acid) 98.07%
    Ibiglustat (Venglustat) L-Malic acid 是一种具有口服活性的,可透过血脑屏障的葡萄糖神经酰胺合成酶 (GCS) 抑制剂。Ibiglustat (Venglustat) L-Malic acid 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。
  • HY-17020
    Miglustat

    美格鲁特

    Inhibitor
    Miglustat (N-Butyldeoxynojirimycin) 是一种神经酰胺葡糖基转移酶抑制剂,具有口服活性。Miglustat 可用于 I 型戈谢病的研究。
  • HY-129411
    Sinbaglustat 98.50%
    Sinbaglustat (OGT2378) 是葡萄糖神经酰胺合成酶 (GCS) 和非溶酶体葡萄糖神经酰胺酶 (GBA2) 的双重抑制剂。Sinbaglustat 是一种可透过血脑屏障的的口服N-烷基亚氨基糖。Sinbaglustat 可用于与溶酶体功能障碍相关的中枢神经退行性疾病的研究。
  • HY-110363
    Miglustat-d9 hydrochloride
    Miglustat-d9 (N-Butyldeoxynojirimycin-d9) hydrochloride 是 Miglustat (hydrochloride) 的氘代物。Miglustat hydrochloride 是一种葡萄糖神经酰胺合成酶抑制剂,可作用于 I 型戈谢病。
  • HY-17020S
    Miglustat-d9
    Miglustat-d9 是 Miglustat 的氘代物。Miglustat (N-Butyldeoxynojirimycin) 是葡萄糖神经酰胺合成酶抑制剂,可作用于I型戈谢病。