1. 重组蛋白
  2. Cytokines and Growth Factors
  3. PDGFs & PDGFRs

PDGFs & PDGFRs  (血小板源性生长因子及受体)

血小板源生长因子 (PDGF) 是一种有效的促有丝分裂因子 (有丝分裂原),能调节结缔组织和发育中神经系统的细胞生长和分裂。PDGF家族由 5 个不同的多肽链 (亚型) 组成:PDGF-AA、PDGF-AB、PDGF-BB、PDGF-CC 和 PDGF-DD。PDGF 的两个受体 PDGFRα和PDGFRβ,属于酪氨酸激酶受体 (RTK)。PDGFRα 信号控制原肠的形成和颅、心脏神经嵴、肺、肠、皮肤、肾、骨骼、性腺和神经保护组织的发育,而 PDGFRβ 信号在早期造血和血管形成中具有重要作用。PDGF 参与创面愈合,调节血管张力,维持组织液静水压。PDGF信号也参与了各种增生性疾病 (部分肿瘤、动脉粥样硬化和再狭窄以及纤维变性) 的发病机制。

Platelet-derived growth factors (PDGFs) are potent mitogenic factors (mitogens) that regulate cell growth and division, in connective tissue and the developing nervous system. The PDGF family consists of five different polypeptide chains (subunits): PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. The two receptors for PDGFs are PDGFRα and PDGFRβ, which belong to receptor tyrosine kinase (RTK). PDGFRα signaling controls gastrulation and the development of the cranial, cardiac neural crest, lung, intestine, skin, kidney, skeleton, gonads, and neuroprotective tissues, whereas PDGFRβ signaling has been well established in early hematopoiesis and blood vessel formation. PDGFs participate in wound healing, regulation of blood vessel tonus, and maintenance of the interstitial fluid pressure. PDGF signaling is also involved in the pathogenesis of various proliferative diseases (certain tumors, atherosclerosis and restenosis, and fibrotic conditions).

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